Literature DB >> 6150862

5HT-receptor antagonist properties of SCH 23390 in vascular smooth muscle and brain.

P E Hicks, H Schoemaker, S Z Langer.   

Abstract

The dopamine D1-receptor antagonist SCH 23390 was a potent competitive antagonist of 5HT-induced vasoconstriction in the isolated perfused rat tail artery preparation (pA2 8.17) but a very weak antagonist of phenylephrine-induced responses (pA2 5.94). In rat brain cerebral cortex, SCH 23390 inhibited 5-HT2-sensitive [3H]spiperone binding with an IC50 of 112 nM. Binding of [3H]5HT to 5HT1 receptors in the cortex was inhibited by SCH 23390 with an IC50 of 2.49 microM. SCH 23390 has significant affinity for 5HT receptors in addition to the reported selective dopamine D1-receptor antagonist properties.

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Year:  1984        PMID： 6150862     DOI： 10.1016/0014-2999(84)90628-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  14 in total

1.  Blockade of D1 dopamine receptors in the ventral tegmental area decreases cocaine reward: possible role for dendritically released dopamine.

Authors:  R Ranaldi; R A Wise
Journal:  J Neurosci       Date:  2001-08-01       Impact factor: 6.167

2.  Serotonin stimulates phospholipase A2 and the release of arachidonic acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositolphospholipid hydrolysis.

Authors:  C C Felder; R Y Kanterman; A L Ma; J Axelrod
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

3.  Differential tolerance to cataleptic effects of SCH 23390 and haloperidol after repeated administration.

Authors:  J Lappalainen; J Hietala; E Syvälahti
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

4.  Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory.

Authors:  Joshua Sariñana; Takashi Kitamura; Patrik Künzler; Lisa Sultzman; Susumu Tonegawa
Journal:  Proc Natl Acad Sci U S A       Date:  2014-05-19       Impact factor: 11.205

5.  Activation of the 5-HT1C receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393.

Authors:  C A Briggs; N J Pollock; D E Frail; C L Paxson; R F Rakowski; C H Kang; J W Kebabian
Journal:  Br J Pharmacol       Date:  1991-12       Impact factor: 8.739

6.  Drugs acting at D-1 and D-2 dopamine receptors induce identical purposeless chewing in rats which can be differentiated by cholinergic manipulation.

Authors:  P Collins; C L Broekkamp; P Jenner; C D Marsden
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

7.  The benzazepine SCH 23390 increases plasma levels of cortisol in the conscious dog.

Authors:  M Goiny; M Herrera-Marschitz; K Uvnäs-Moberg; S Cekan; U Ungerstedt
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-01       Impact factor: 3.000

8.  Actions of dopamine and dopaminergic drugs on cloned serotonin receptors expressed in Xenopus oocytes.

Authors:  R M Woodward; M M Panicker; R Miledi
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-15       Impact factor: 11.205

9.  Effects of the putative D-1 antagonist SCH 23390 on stereotyped behaviour induced by the D-2 agonist RU24213.

Authors:  M T Pugh; K M O'Boyle; A G Molloy; J L Waddington
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

10.  A functional response to D1 dopamine receptor stimulation in the central nervous system: inhibition of the release of [3H]-serotonin from the rat substantia nigra.

Authors:  S Benkirane; S Arbilla; S Z Langer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-05       Impact factor: 3.000
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