Metabolic changes induced by combined prolonged exercise and low-calorie intake in man.

Thirteen middle-aged women and 10 men walked 344 km during 7 days. The daily walking distances were 57, 53, 67, 53, 41, 36, and 37 km at an average speed of 3.5 km X h-1. During the hike the subjects drank water, mineral drinks, and juices ad libitum. Except for some natural products, no food intake was allowed. During the hike the body weight and serum protein concentration of the subjects decreased by about 7%, on average. Serum triglyceride and total cholesterol decreased drastically, about 30-40% during the hike, but HDL-cholesterol showed a tendency to increase, giving a 40% increment in HDL/total cholesterol ratio. Serum free fatty acids rose 1.5-2 times above the starting level. Serum glucose and evening insulin levels decreased significantly during the hike. Serum cortisol in evening samples after the daily walking and plasma norepinephrine concentrations were significantly increased, reflecting the immediate daily response to the combined fasting and walking. Serum testosterone levels decreased in men but not in women, indicating the involvement of the LH-testis pathway in the decrease obtained. Serum ASAT activity rose to about three times the starting level during the hike, whereas gamma-GT activity gradually decreased. These marked metabolic changes caused by combined fasting and several days exercise were in many respects (as in cholesterol, HDL/total cholesterol ratio or testosterone levels) more pronounced than those earlier reported to be caused by exercise or fasting alone.