Methyl 5(6)-4-2-pyridyl piperazino carbamoyl benzimidazole-2-carbamate--a new broad spectrum anthelmintic.

Methyl 5(6)-4-2-pyridyl piperazino carbamoyl benzimidazole-2-carbamate (CDRI Comp. 81-470) was tested against various nematode and cestode infections in different experimental and domestic animals. The compound showed 100% effectivity against adult of Ancylostoma ceylanicum (hookworm) in hamsters (6.25 mg/kg p.o. X 1), Nippostrongylus brasiliensis (trichostrongylid) in rats (100 mg/kg p.o. X 3), Hymenolepis nana (cestode) in rats (25 mg/kg p.o. X 1) and Syphacia obvelata (oxyurid) in mice (12.5 mg/kg p.o. X 3). It was also found highly effective against artificial and natural helminth parasites of higher animals. The compound removed all, A. caninum and A. ceylanicum (hookworms) and Toxocara sp. (ascarid) from dogs at a dose of 10 mg/kg p.o. X 3; A. tubaeformis (hookworm) and Toxocara sp. at 25 mg/kg p.o. X 3 and 2.5 mg/kg p.o. X 3 respectively from cats and Ascaridia galli (ascarid) at 10 mg/kg p.o. X 3 from fowl. The compound in doses of 1500 mg/kg by oral route and 1000 mg/kg by i.p. route did not cause any mortality or produce adverse effect in mice. The expanded anthelmintic action and large therapeutic index indicate compound's great anthelmintic potentiality.