Literature DB >> 6150494

The effects of GABA and benzodiazepine receptor antagonists on the anti-conflict actions of diazepam or ethanol.

S Liljequist, J A Engel.   

Abstract

The effects of picrotoxin, bicuculline or RO 15-1788 on the anti-conflict action(s) of diazepam or ethanol were studied in rats using a modified Vogel's conflict test procedure. RO 15-1788 antagonized the anti-punishment effects of diazepam (2.5 mg/kg, IP), whereas various doses of bicuculline or picrotoxin did not interfere with diazepam's anti-conflict effect in this test situation. The anti-conflict action of ethanol (2 g/kg, IP) was antagonized by picrotoxin (1.0 mg/kg, IP), whereas both bicuculline and RO 15-1788 were without effect on the increased punishment response produced by ethanol. These data suggest that the anti-conflict properties of ethanol are at least partially mediated through an enhancement of central GABAergic activity.

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Year:  1984        PMID： 6150494     DOI： 10.1016/s0091-3057(84)80033-7

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  21 in total

1.  Cerebellar GABAA receptor binding and function in vitro in two rat lines developed for high and low alcohol sensitivity.

Authors:  M Uusi-Oukari; E R Korpi
Journal:  Neurochem Res       Date:  1989-08       Impact factor: 3.996

2.  The effects of FG 7142 and RO 15-1788 on the release of punished responding produced by chlordiazepoxide and ethanol in the rat.

Authors:  G F Koob; C Braestrup; K Thatcher Britton
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

3.  Does the benzodiazepine antagonist Ro 15-1788 antagonize the action of ethanol?

Authors:  U Klotz; G Ziegler; B Rosenkranz; G Mikus
Journal:  Br J Clin Pharmacol       Date:  1986-11       Impact factor: 4.335

4.  Quantification of ethanol's antipunishment effect in humans using the generalized matching equation.

Authors:  Erin B Rasmussen; M Christopher Newland
Journal:  J Exp Anal Behav       Date:  2009-09       Impact factor: 2.468

5.  Benzodiazepine antagonist RO 15-1788 partly reverses some anxiolytic effects of ethanol in the mouse.

Authors:  C Belzung; E Vogel; R Misslin
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

6.  Influence of changes in the effectiveness of blockade of the benzodiazepine-GABA ionophore complex on the reproduction of the amnestic memory trace in mice after preliminary administration of diazepam.

Authors:  N I Dubrovina; R I Parkhomenko
Journal:  Neurosci Behav Physiol       Date:  1990 May-Jun

7.  Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes.

Authors:  P D Suzdak; R D Schwartz; P Skolnick; S M Paul
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

8.  The benzodiazepine inverse agonist RO19-4603 exerts prolonged and selective suppression of ethanol intake in alcohol-preferring (P) rats.

Authors:  H L June; J M Murphy; J J Mellor-Burke; L Lumeng; T K Li
Journal:  Psychopharmacology (Berl)       Date:  1994-07       Impact factor: 4.530

9.  Alcohol attenuates amygdala-frontal connectivity during processing social signals in heavy social drinkers: a preliminary pharmaco-fMRI study.

Authors:  Stephanie M Gorka; Daniel A Fitzgerald; Andrea C King; K Luan Phan
Journal:  Psychopharmacology (Berl)       Date:  2013-04-13       Impact factor: 4.530

Review 10.  Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development?

Authors:  M Wallner; R W Olsen
Journal:  Br J Pharmacol       Date:  2008-02-18       Impact factor: 8.739
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