Literature DB >> 6149946

The contractions induced in rat and guinea-pig aortic strips by the alpha 2-adrenoceptor selective agonists B-HT 920 and UK 14,304 are mediated by alpha 1-adrenoceptors.

J J Beckeringh, M J Thoolen, A De Jonge, B Wilffert, P B Timmermans, P A Van Zwieten.   

Abstract

The alpha-adrenergic action of the selective alpha 2-adrenoceptor agonists B-HT 920 and UK 14,304 was investigated on helically cut preparations of rat and guinea-pig isolated aorta. The alpha 1-adrenoceptor selective stimulant (-)-phenylephrine was included for comparison. All agonists induced concentration-dependent contractions in both preparations. Calcium entry blockade by D 600 almost abolished the contractions evoked by B-HT 920 and UK 14,304 in rat aorta while those evoked in guinea-pig aorta were less strongly affected. Contractions elicited by (-)-phenylephrine were moderately impaired by D 600 in rat aorta whereas there was only a limited effect in guinea-pig aorta. Analysis of the prazosin and yohimbine antagonism of B-HT 920- and UK 14,304-evoked contractions showed the involvement of alpha 1-like adrenoceptors in rat and guinea-pig aorta, prazosin being approximately 1000 times more potent that yohimbine. The results show that B-HT 920 and UK 14,304 contract rat and guinea-pig aorta via alpha 1-like adrenoceptors which are not identical. It is submitted that rat and guinea-pig alpha 1-adrenoceptors activate different contractile processes.

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Year:  1984        PMID： 6149946     DOI： 10.1016/0014-2999(84)90394-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  10 in total

1.  Differences between full and partial alpha-adrenoceptor agonists in eliciting phasic and tonic types of responses in the longitudinal smooth muscle of the rat portal vein.

Authors:  H R Schwietert; D Wilhelm; B Wilffert; P A van Zwieten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-08       Impact factor: 3.000

2.  Alpha-1 and alpha-2 adrenoceptor agonists induce vasoconstriction of the normotensive rat caudal artery in vitro by stimulation of a heterogeneous population of alpha-1 adrenoceptors.

Authors:  J Atkinson; N Trescases; C Benedek; N Boillat; A K Fouda; F Krause; M C Pitton; C Rafizadeh; J C de Rivaz; M Sautel
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-11       Impact factor: 3.000

3.  Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using intracellular Ca(2+) changes: evidence for cross-talk between recombinant alpha(2A)- and native alpha(1)-adrenoceptors.

Authors:  P H Reynen; G R Martin; R M Eglen; S J MacLennan
Journal:  Br J Pharmacol       Date:  2000-04       Impact factor: 8.739

4.  Influence of the vascular endothelium on agonist-induced contractions and relaxations in rat aorta.

Authors:  G R Bullock; S G Taylor; A H Weston
Journal:  Br J Pharmacol       Date:  1986-12       Impact factor: 8.739

5.  Impairment of relaxations to acetylcholine and nitric oxide by a phorbol ester in rat isolated aorta.

Authors:  K J Morrison; D Pollock
Journal:  Br J Pharmacol       Date:  1990-10       Impact factor: 8.739

6.  Sources of calcium and alpha 1-adrenoceptor-mediated contraction in rat tail artery.

Authors:  A Tabernero; N M Vivas; E Vila
Journal:  Br J Pharmacol       Date:  1996-08       Impact factor: 8.739

7.  Alfuzosin, a selective alpha 1-adrenoceptor antagonist in the lower urinary tract.

Authors:  F Lefèvre-Borg; S E O'Connor; H Schoemaker; P E Hicks; J Lechaire; E Gautier; F Pierre; C Pimoule; P Manoury; S Z Langer
Journal:  Br J Pharmacol       Date:  1993-08       Impact factor: 8.739

8.  Effect of NG-nitro-L-arginine methylester (L-NAME) on functional and biochemical alpha 1-adrenoceptor-mediated responses in rat blood vessels.

Authors:  A Tabernero; J Giraldo; E Vila
Journal:  Br J Pharmacol       Date:  1996-02       Impact factor: 8.739

9.  Effects of the irreversible alpha-adrenoceptor antagonists phenoxybenzamine and benextramine on the effectiveness of nifedipine in inhibiting alpha 1- and alpha 2-adrenoceptor mediated vasoconstriction in pithed rats.

Authors:  P B Timmermans; M J Thoolen; M J Mathy; B Wilffert; A de Jonge; P A van Zwieten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-06       Impact factor: 3.000

10.  Enhancement of contractile responses to partial alpha-adrenoceptor agonists during warming in rat aorta.

Authors:  Y Arabori; H Kitagawa; H Kohei
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-12       Impact factor: 3.000
  10 in total

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