The influence of topical beta-blockers on the breakup time.

In a double-blind masked study with 100 young and healthy subjects we compared the influence of the beta-blocking agents timolol and metipranol on breakup time and their tolerance. While metipranolol provoked a slight burning sensation, timolol was well tolerated. Both beta-blockers, however, led to an equally enormous reduction in BUT in short-term observations.

RCT Entities:   Population Interventions Outcomes