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Literature DB >> 6149296

The effect of different oils on the absorption of probucol in the rat.

Abstract

The effect of oily vehicles on the gastrointestinal absorption of the hypocholesterolaemic agent probucol has been investigated in the rat. The plasma concentration was determined following its administration in arachis oil (peanut oil), Miglyol 812 (fractionated coconut oil) and liquid paraffin. The total absorption of the drug, calculated as the area under the plasma concentration time curve, was significantly greater for the arachis oil formulation than with the other vehicles. The drug was selectively absorbed via the lymphatic system, lymph drug concentrations being highest following co-administration of arachis oil.

Entities: Chemical Disease Species

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Year: 1984 PMID： 6149296 DOI： 10.1111/j.2042-7158.1984.tb04919.x

Source DB: PubMed Journal: J Pharm Pharmacol ISSN： 0022-3573 Impact factor: 3.765

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Cited

14 in total

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2. Comparison of the lymphatic transport of halofantrine administered in disperse systems containing three different unsaturated fatty acids.

Authors: R Holm; A Müllertz; G P Pedersen; H G Kristensen
Journal: Pharm Res Date: 2001-09 Impact factor: 4.200

3. Gelatin-acacia microcapsules for trapping micro oil droplets containing lipophilic drugs and ready disintegration in the gastrointestinal tract.

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4. Further studies on the antinociceptive effects of delta 6-THC-7-oic acid.

Authors: S A Doyle; S H Burstein; W L Dewey; S P Welch
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5. Use of a dynamic in vitro lipolysis model to rationalize oral formulation development for poor water soluble drugs: correlation with in vivo data and the relationship to intra-enterocyte processes in rats.

Authors: Arik Dahan; Amnon Hoffman
Journal: Pharm Res Date: 2006-08-11 Impact factor: 4.200

The effect of different oils on the absorption of probucol in the rat.

1. Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats.

2. Comparison of the lymphatic transport of halofantrine administered in disperse systems containing three different unsaturated fatty acids.

3. Gelatin-acacia microcapsules for trapping micro oil droplets containing lipophilic drugs and ready disintegration in the gastrointestinal tract.

4. Further studies on the antinociceptive effects of delta 6-THC-7-oic acid.

5. Use of a dynamic in vitro lipolysis model to rationalize oral formulation development for poor water soluble drugs: correlation with in vivo data and the relationship to intra-enterocyte processes in rats.

6. Enhancement of oral moxidectin bioavailability in rabbits by lipid co-administration.

7. In vitro model for ciclosporin intestinal absorption in lipid vehicles.

8. In vivo model for ciclosporin intestinal absorption in lipid vehicles.

9. Self-microemulsifying drug-delivery system for improved oral bioavailability of probucol: preparation and evaluation.

10. Influence of Organic Solvents on Secondary Brain Damage after Experimental Traumatic Brain Injury.