Literature DB >> 6149295

The hydroxy-hexanydronaphthoxazines: a new group of very potent and selective dopamine agonists.

A S Horn, B Hazelhoff, D Dijkstra, J B de Vries, T B Mulder, P Timmermans, H Wynberg.   

Abstract

Replacement of the pyrrole ring system in the dopaminergic oxaergolines (e.g. RU 29717) by a phenolic OH group leads to the hydroxy-hexahydronaphthoxazines, a new group of potent dopamine agonists which exhibit increased selectivity due to their lower affinity for adrenergic and 5-HT receptors.

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Year:  1984        PMID: 6149295     DOI: 10.1111/j.2042-7158.1984.tb04918.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN: 0022-3573            Impact factor:   3.765


  3 in total

Review 1.  Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug design.

Authors:  Thomas M Keck; Caitlin Burzynski; Lei Shi; Amy Hauck Newman
Journal:  Adv Pharmacol       Date:  2014

2.  Endocrine and neurochemical effects of (+)-PHNO, a dopamine D2 agonist.

Authors:  C M Gust; S K Hemrick-Luecke; R W Fuller
Journal:  J Neural Transm       Date:  1989       Impact factor: 3.575

3.  Effects of D-2 agonists on the release of dopamine: localization of the mechanism of action.

Authors:  W Timmerman; J B De Vries; B H Westerink
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-12       Impact factor: 3.000

  3 in total

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