Literature DB >> 6148400

Determination of biological activity of adinazolam and its metabolites.

V H Sethy, R J Collins, E G Daniels.   

Abstract

Adinazolam and its metabolites inhibit [3H]flunitrazepam binding in-vitro. The binding affinities of these compounds is significantly enhanced in the presence of 10-5 M muscimol, indicating that both adinazolam and its metabolites are benzodiazepine agonists. In-vivo metabolism of adinazolam results in the formation of active metabolites.

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Year:  1984        PMID： 6148400     DOI： 10.1111/j.2042-7158.1984.tb04449.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  9 in total

1.  Adinazolam pharmacokinetics and behavioral effects following administration of 20-60 mg oral doses of its mesylate salt in healthy volunteers.

Authors:  J C Fleishaker; J P Phillips
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

2.  The pharmacokinetics and pharmacodynamics of adinazolam: multi-ethnic comparisons.

Authors:  K Ajir; M Smith; K M Lin; J C Fleishaker; J H Chambers; D Anderson; I Nuccio; Y Zheng; R E Poland
Journal:  Psychopharmacology (Berl)       Date:  1997-02       Impact factor: 4.530

3.  Extent and variability of the first-pass elimination of adinazolam mesylate in healthy male volunteers.

Authors:  J C Fleishaker; H Friedman; S R Pollock
Journal:  Pharm Res       Date:  1991-02       Impact factor: 4.200

4.  N-desmethyladinazolam pharmacokinetics and behavioral effects following administration of 10-50 mg oral doses in healthy volunteers.

Authors:  J C Fleishaker; T C Smith; H Friedman; J P Phillips
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

5.  Influence of repeated administration of cimetidine on the pharmacokinetics and pharmacodynamics of adinazolam in healthy subjects.

Authors:  R Hulhoven; J P Desager; S Cox; C Harvengt
Journal:  Eur J Clin Pharmacol       Date:  1988       Impact factor: 2.953

6.  Pharmacokinetic and pharmacodynamic comparison of immediate-release and sustained-release adinazolam mesylate tablets after single- and multiple-dose administration.

Authors:  J C Fleishaker; C E Wright
Journal:  Pharm Res       Date:  1992-04       Impact factor: 4.200

7.  Multiple-dose pharmacokinetics and pharmacodynamics of adinazolam in elderly subjects.

Authors:  J C Fleishaker; J P Phillips; T C Smith; R B Smith
Journal:  Pharm Res       Date:  1989-05       Impact factor: 4.200

8.  Mechanism of triazolo-benzodiazepine and benzodiazepine action in anxiety and depression: behavioral studies with concomitant in vivo CA1 hippocampal norepinephrine and serotonin release detection in the behaving animal.

Authors:  P A Broderick; O Hope; P Jeannot
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  1998-02       Impact factor: 5.067

Review 9.  'New/Designer Benzodiazepines': An Analysis of the Literature and Psychonauts' Trip Reports.

Authors:  Laura Orsolini; John M Corkery; Stefania Chiappini; Amira Guirguis; Alessandro Vento; Domenico De Berardis; Duccio Papanti; Fabrizio Schifano
Journal:  Curr Neuropharmacol       Date:  2020       Impact factor: 7.363
  9 in total

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