Literature DB >> 6148039

Underwater life support based on immobilized oxygen carriers.

C Bonaventura, J Bonaventura, I R Hooper, T Marshall.   

Abstract

One of the primary problems that hinders humans in their efforts to explore and develop the ocean realms is the lack of a ready supply of oxygen. Practical methods have not yet been devised for using the vast amount of oxygen dissolved in ocean waters for human life support in an undersea environment. Fish and other water-breathing animals have solved this problem by utilizing hemoglobin as a molecular oxygen pump. To achieve a similar oxygen extraction capability, we have explored various methods of oxygen extraction that are based on immobilized forms of hemoglobin. Improved methods for immobilizing hemoglobin or other oxygen carrying molecules and a method for extracting the available dissolved oxygen from natural waters and other fluids are described. The techniques that have been developed allow for immobilization of oxygen carriers at high concentration in a state where they are capable of reversible oxygen binding, and also allow for regeneration of the carrier in the event of oxidation of the oxygen-binding site.

Entities:  

Mesh:

Substances:

Year:  1984        PMID: 6148039     DOI: 10.1007/bf02798375

Source DB:  PubMed          Journal:  Appl Biochem Biotechnol        ISSN: 0273-2289            Impact factor:   2.926


  8 in total

Review 1.  Hemoglobins and hemocyanins: comparative aspects of structure and function.

Authors:  J Bonaventura; C Bonaventura; B Sullivan
Journal:  J Exp Zool       Date:  1975-10

2.  Organic compound synthesis on the primitive earth.

Authors:  S L MILLER; H C UREY
Journal:  Science       Date:  1959-07-31       Impact factor: 47.728

3.  Solution behavior of a synthetic myoglobin active site.

Authors:  C K Chang; T G Traylor
Journal:  J Am Chem Soc       Date:  1973-08-22       Impact factor: 15.419

4.  Thin-layer methods for determination of oxygen binding curves of hemoglobin solutions and blood.

Authors:  G N Lapennas; J M Colacino; J Bonaventura
Journal:  Methods Enzymol       Date:  1981       Impact factor: 1.600

5.  The effect of 4-isothiocyanatobenzene sulfonic acid on the oxygen affinity of human hemoglobin.

Authors:  D L Currell; B Law; M Stevens; P Murata; C Ioppolo; F Martini
Journal:  Biochem Biophys Res Commun       Date:  1981-09-16       Impact factor: 3.575

6.  Labeling of hemoglobin with pyridoxal phosphate.

Authors:  R Benesch; R E Benesch; S Kwong; A S Acharya; J M Manning
Journal:  J Biol Chem       Date:  1982-02-10       Impact factor: 5.157

7.  Differences in the interaction of 2,3-diphosphoglycerate with certain mammalian hemoglobins.

Authors:  H F Bunn
Journal:  Science       Date:  1971-06-04       Impact factor: 47.728

8.  Coboglobins: oxygen-carrying cobalt-reconstituted hemoglobin and myoglobin.

Authors:  B M Hoffman; D H Petering
Journal:  Proc Natl Acad Sci U S A       Date:  1970-10       Impact factor: 11.205

  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.