Literature DB >> 6148019

Regulation of proximal bicarbonate reabsorption.

M G Cogan, R J Alpern.   

Abstract

Under free-flow conditions, alterations in acid-base and extracellular volume status affect absolute proximal bicarbonate reabsorption. Microperfusion studies have characterized the individual determinants of the active and passive components of proximal acidification. These determinants include luminal bicarbonate concentration, luminal flow rate, peritubular bicarbonate concentration, PCO2, extracellular volume status, and solute-solvent interactions. When these individual determinants are integrated into a computer-simulated model of absolute proximal bicarbonate reabsorption, the results agree well with the in vivo free-flow data.

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Year:  1984        PMID： 6148019     DOI： 10.1152/ajprenal.1984.247.3.F387

Source DB:  PubMed          Journal:  Am J Physiol        ISSN： 0002-9513


  10 in total

1.  Distal tubule bicarbonate accumulation in vivo. Effect of flow and transtubular bicarbonate gradients.

Authors:  M Iacovitti; L Nash; L N Peterson; J Rochon; D Z Levine
Journal:  J Clin Invest       Date:  1986-12       Impact factor: 14.808

2.  Axial heterogeneity of bicarbonate, chloride, and water transport in the rat proximal convoluted tubule. Effects of change in luminal flow rate and of alkalemia.

Authors:  F Y Liu; M G Cogan
Journal:  J Clin Invest       Date:  1986-12       Impact factor: 14.808

3.  Parallel adaptation of the rabbit renal cortical sodium/proton antiporter and sodium/bicarbonate cotransporter in metabolic acidosis and alkalosis.

Authors:  T Akiba; V K Rocco; D G Warnock
Journal:  J Clin Invest       Date:  1987-08       Impact factor: 14.808

4.  Axial heterogeneity of intracellular pH in rat proximal convoluted tubule.

Authors:  E Pastoriza-Munoz; R M Harrington; M L Graber
Journal:  J Clin Invest       Date:  1987-07       Impact factor: 14.808

Review 5.  Renal tubular acidosis.

Authors:  J Rodríguez-Soriano; A Vallo
Journal:  Pediatr Nephrol       Date:  1990-05       Impact factor: 3.714

6.  Sodium-hydrogen exchange and glucose transport in renal microvillus membrane vesicles from rats with diabetes mellitus.

Authors:  R C Harris; B M Brenner; J L Seifter
Journal:  J Clin Invest       Date:  1986-03       Impact factor: 14.808

7.  Chronic hypercapnia stimulates proximal bicarbonate reabsorption in the rat.

Authors:  M G Cogan
Journal:  J Clin Invest       Date:  1984-12       Impact factor: 14.808

8.  Effect of in vitro metabolic acidosis on luminal Na+/H+ exchange and basolateral Na+:HCO3- cotransport in rabbit kidney proximal tubules.

Authors:  M Soleimani; G L Bizal; T D McKinney; Y J Hattabaugh
Journal:  J Clin Invest       Date:  1992-07       Impact factor: 14.808

9.  Bicarbonate transport along the loop of Henle. I. Microperfusion studies of load and inhibitor sensitivity.

Authors:  G Capasso; R Unwin; S Agulian; G Giebisch
Journal:  J Clin Invest       Date:  1991-08       Impact factor: 14.808

10.  Paracellular bicarbonate flux across human cystic fibrosis airway epithelia tempers changes in airway surface liquid pH.

Authors:  Ian M Thornell; Tayyab Rehman; Alejandro A Pezzulo; Michael J Welsh
Journal:  J Physiol       Date:  2020-07-24       Impact factor: 6.228
  10 in total

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