Literature DB >> 6147205

Expression of cell surface P-glycoprotein by an adriamycin-resistant murine fibrosarcoma.

R Giavazzi, N Kartner, I R Hart.   

Abstract

Analysis of the cell membrane of Adriamycin (doxorubicin)-resistant UV-2237 ADMR murine fibrosarcoma cells revealed a 170,000-dalton component that is not found in the drug-sensitive parent or revertant cells. Immunoblot (Western blot) analysis showed that this component is similar to the 170,000-dalton P-glycoprotein found on the surface of Chinese hamster ovary cells that exhibit multidrug resistance. Thus, multidrug resistance and P-glycoprotein expression apparently can occur in a wide variety of cells, including the metastatic murine solid tumor cell line described here.

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Year:  1984        PMID： 6147205     DOI： 10.1007/bf00257134

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  13 in total

1.  Drug resistance and membrane alteration in mutants of mammalian cells.

Authors:  V Ling
Journal:  Can J Genet Cytol       Date:  1975-12

2.  A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants.

Authors:  R L Juliano; V Ling
Journal:  Biochim Biophys Acta       Date:  1976-11-11

3.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

4.  Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

Authors:  W T Beck; T J Mueller; L R Tanzer
Journal:  Cancer Res       Date:  1979-06       Impact factor: 12.701

5.  Metastatic heterogeneity of cells from an ultraviolet light-induced murine fibrosarcoma of recent origin.

Authors:  M L Kripke; E Gruys; I J Fidler
Journal:  Cancer Res       Date:  1978-09       Impact factor: 12.701

6.  Membrane alterations associated with progressive adriamycin resistance.

Authors:  C Wheeler; R Rader; D Kessel
Journal:  Biochem Pharmacol       Date:  1982-08-15       Impact factor: 5.858

7.  Purification of P-glycoprotein from plasma membrane vesicles of Chinese hamster ovary cell mutants with reduced colchicine permeability.

Authors:  J R Riordan; V Ling
Journal:  J Biol Chem       Date:  1979-12-25       Impact factor: 5.157

8.  DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression.

Authors:  P G Debenham; N Kartner; L Siminovitch; J R Riordan; V Ling
Journal:  Mol Cell Biol       Date:  1982-08       Impact factor: 4.272

9.  The role of membranes in the mechanism of action of the antineoplastic agent adriamycin. Spin-labeling studies with chronically hypoxic and drug-resistant tumor cells.

Authors:  J A Siegfried; K A Kennedy; A C Sartorelli; T R Tritton
Journal:  J Biol Chem       Date:  1983-01-10       Impact factor: 5.157

10.  Isolation and preliminary characterization of an Adriamycin-resistant murine fibrosarcoma cell line.

Authors:  R Giavazzi; E Scholar; I R Hart
Journal:  Cancer Res       Date:  1983-05       Impact factor: 12.701
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  4 in total

1.  Expressions of resistance and cross-resistance in teniposide-resistant L1210 cells.

Authors:  D Roberts; T Lee; E Parganas; L Wiggins; J Yalowich; R Ashmun
Journal:  Cancer Chemother Pharmacol       Date:  1987       Impact factor: 3.333

2.  Induced multidrug resistance in murine leukemia L1210 and associated changes in a surface-membrane glycoprotein.

Authors:  M Volm; M Bak; T Efferth; J Mattern
Journal:  J Cancer Res Clin Oncol       Date:  1989       Impact factor: 4.553

3.  Development and initial characterization of a mitomycin C-resistant colon cancer cell line variant.

Authors:  R R Perry; B R Greaves; Y Kang
Journal:  Cancer Chemother Pharmacol       Date:  1993       Impact factor: 3.333

4.  2-APB and CBD-Mediated Targeting of Charged Cytotoxic Compounds Into Tumor Cells Suggests the Involvement of TRPV2 Channels.

Authors:  Hagit Neumann-Raizel; Asaf Shilo; Shaya Lev; Maxim Mogilevsky; Ben Katz; David Shneor; Yoav D Shaul; Andreas Leffler; Alberto Gabizon; Rotem Karni; Alik Honigman; Alexander M Binshtok
Journal:  Front Pharmacol       Date:  2019-10-15       Impact factor: 5.810
  4 in total

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