Literature DB >> 6146926

The interaction of sea anemone and scorpion neurotoxins with tetrodotoxin-resistant Na+ channels in rat myoblasts. A comparison with Na+ channels in other excitable and non-excitable cells.

C Frelin, P Vigne, H Schweitz, M Lazdunski.   

Abstract

The properties of interactions of several polypeptide neurotoxins isolated from sea anemone and scorpion venom with Na+ channels of rat myoblasts, chick myotubes, neuroblastoma cells, and fibroblasts have been compared. Tetrodotoxin (TTX)-resistant Na+ channels appear to be much more sensitive to the action of sea anemone toxins than TTX-sensitive Na+ channels but have the same affinity for scorpion neurotoxins. This conclusion holds both for Na+ channels that can be activated electrically and for silent forms of Na+ channels. The sensitivity to sea anemone toxins of the different types of Na+ channels that have been studied suggests the existence of multiple forms of Na+ channels.

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Year:  1984        PMID： 6146926

Source DB:  PubMed          Journal:  Mol Pharmacol        ISSN： 0026-895X            Impact factor:   4.436


  9 in total

Review 1.  Site-3 toxins and cardiac sodium channels.

Authors:  Dorothy A Hanck; Michael F Sheets
Journal:  Toxicon       Date:  2006-09-27       Impact factor: 3.033

2.  The sodium channels of the neuroblastoma x glioma 108 CC 15 hybrid cell change their sensitivity for volatile and local anesthetics upon continuous passage.

Authors:  P W Tas; H G Kress; K Koschel
Journal:  J Neural Transm       Date:  1989       Impact factor: 3.575

3.  Voltage-dependent calcium and potassium channels in Schwann cells cultured from dorsal root ganglia of the mouse.

Authors:  T Amédée; E Ellie; B Dupouy; J D Vincent
Journal:  J Physiol       Date:  1991-09       Impact factor: 5.182

4.  Cultured myotubes from skeletal muscle of adult rats. Characterization and action of Anemonia sulcata toxin II.

Authors:  I Tesseraux; M Gülden; O Wassermann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-08       Impact factor: 3.000

5.  Calcicludine, a venom peptide of the Kunitz-type protease inhibitor family, is a potent blocker of high-threshold Ca2+ channels with a high affinity for L-type channels in cerebellar granule neurons.

Authors:  H Schweitz; C Heurteaux; P Bois; D Moinier; G Romey; M Lazdunski
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-01       Impact factor: 11.205

6.  Different types of Ca2+ channels in mammalian skeletal muscle cells in culture.

Authors:  C Cognard; M Lazdunski; G Romey
Journal:  Proc Natl Acad Sci U S A       Date:  1986-01       Impact factor: 11.205

7.  Different functional states of tetrodotoxin sensitive and tetrodotoxin resistant Na+ channels occur during the in vitro development of rat skeletal muscle.

Authors:  C Frelin; H P Vijverberg; G Romey; P Vigne; M Lazdunski
Journal:  Pflugers Arch       Date:  1984-10       Impact factor: 3.657

8.  Na+ channels as sites of action of the cardioactive agent DPI 201-106 with agonist and antagonist enantiomers.

Authors:  G Romey; U Quast; D Pauron; C Frelin; J F Renaud; M Lazdunski
Journal:  Proc Natl Acad Sci U S A       Date:  1987-02       Impact factor: 11.205

9.  The Anemonia sulcata Toxin BDS-I Protects Astrocytes Exposed to Aβ1-42 Oligomers by Restoring [Ca2+]i Transients and ER Ca2+ Signaling.

Authors:  Ilaria Piccialli; Valentina Tedeschi; Francesca Boscia; Roselia Ciccone; Antonella Casamassa; Valeria de Rosa; Paolo Grieco; Agnese Secondo; Anna Pannaccione
Journal:  Toxins (Basel)       Date:  2020-12-31       Impact factor: 4.546
  9 in total

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