| Literature DB >> 6146718 |
S T Kam, W L Matier, K X Mai, C Barcelon-Yang, R J Borgman, J P O'Donnell, H F Stampfli, C Y Sum, W G Anderson, R J Gorczynski.
Abstract
Novel [(arylcarbonyl)oxy]propanolamines were synthesized and investigated as potential ultrashort-acting beta-adrenergic receptor blockers. Many of these analogues exhibited good potency and short duration. The N-ureidoalkyl analogue 85 (ACC-9089) has a potency equal to propranolol and a duration of action of about 21 min in the dog. It has been selected as a candidate for further clinical study. Structure-activity relationships and structure-duration relationships for these new beta-blockers are also discussed.Entities:
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Year: 1984 PMID： 6146718 DOI： 10.1021/jm00374a013
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446