| Literature DB >> 6146344 |
M J Kendall, D B Jack, C P Quarterman, S R Smith, R Zaman.
Abstract
Higher AUC and Cmax values were obtained for metoprolol, oxprenolol and propranolol in groups receiving the low-dose oestrogen-ethinyl oestradiol oral contraceptive, but statistical significance was reached only with metoprolol AUC. The oral contraceptive had the opposite effect on acebutolol AUC and Cmax but this was not significant. The oral contraceptive had no detectable effects on the tmax and t 1/2 values of any of the beta-adrenoceptor blockers.Entities:
Keywords: Clinical Research; Contraception; Contraceptive Agents; Contraceptive Agents, Female; Contraceptive Methods; Drugs--administraction and dosage; Drugs--analysis; Drugs--pharmacodynamics; Examinations And Diagnoses; Family Planning; Human Volunteers; Laboratory Examinations And Diagnoses; Laboratory Procedures; Oral Contraceptives; Oral Contraceptives, Low-dose; Research Methodology; Treatment
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Year: 1984 PMID： 6146344 PMCID： PMC1463276 DOI： 10.1111/j.1365-2125.1984.tb02435.x
Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335