Literature DB >> 6146318

Rat lung tissue is a site of alpha 1-proteinase inhibitor synthesis: evidence by cell-free translation.

W Budek, P Bünning, P C Heinrich.   

Abstract

Poly(A) +RNA isolated from lungs of normal rats and of rats suffering from experimental inflammation was translated in a cell-free translation mixture from rabbit reticulocytes. The translation products were immunoprecipitated with specific antisera against alpha 1-proteinase inhibitor and alpha 2-macroglobulin. Comparable levels of mRNA for alpha 1-proteinase inhibitor were found in rat lung tissue from control and experimentally inflamed animals. alpha 2-Macroglobulin mRNA could not be detected in rat lung tissue.

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Year:  1984        PMID: 6146318     DOI: 10.1016/0006-291x(84)90488-1

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN: 0006-291X            Impact factor:   3.575


  2 in total

Review 1.  Cytokines regulating acute inflammation and synthesis of acute phase proteins.

Authors:  A Koj
Journal:  Blut       Date:  1985-10

2.  Expression of the alpha-1-antitrypsin gene in mononuclear phagocytes of normal and alpha-1-antitrypsin-deficient individuals.

Authors:  J F Mornex; A Chytil-Weir; Y Martinet; M Courtney; J P LeCocq; R G Crystal
Journal:  J Clin Invest       Date:  1986-06       Impact factor: 14.808

  2 in total

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