Literature DB >> 6146117

A comparison of the effects of N-methyl-D-aspartate and quinolinate on central neurones of the rat.

H McLennan.   

Abstract

The apparent potencies of quinolinate, N-methyl-D-aspartate (NMDA) and quisqualate as excitants administered microelectrophoretically to single central neurones have been compared. In the cerebral cortex of rats NMDA has about 10% and quinolinate about 1% of the potency of quisqualate; in spinal cord quinolinate appears to be 5-fold less active. The excitations evoked by quinolinate and NMDA are blocked in parallel by 2-amino-5-phosphonovalerate, suggesting that they react with a common receptor.

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Year:  1984        PMID： 6146117     DOI： 10.1016/0304-3940(84)90434-8

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  6 in total

1.  Structural requirements for activation of excitatory amino acid receptors in the rat spinal cord in vitro.

Authors:  D S Magnuson; K Curry; M J Peet; H McLennan
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

Review 2.  A review of the in vitro and in vivo neurochemical characterization of the NMDA/PCP/glycine/ion channel receptor macrocomplex.

Authors:  P L Wood; T S Rao; S Iyengar; T Lanthorn; J Monahan; A Cordi; E Sun; M Vazquez; N Gray; P Contreras
Journal:  Neurochem Res       Date:  1990-02       Impact factor: 3.996

3.  Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: protection by melatonin and deprenyl.

Authors:  W M Behan; M McDonald; L G Darlington; T W Stone
Journal:  Br J Pharmacol       Date:  1999-12       Impact factor: 8.739

4.  Evidence for heterogenous glycine domains but conserved multiple states of the excitatory amino acid recognition site of the NMDA receptor: regional binding studies with [3H]glycine and [3H]L-glutamate.

Authors:  R D O'Shea; D T Manallack; E L Conway; L D Mercer; P M Beart
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

5.  Swallowing responses induced by microinjection of glutamate and glutamate agonists into the nucleus tractus solitarius of ketamine-anesthetized rats.

Authors:  J P Kessler; N Cherkaoui; D Catalin; A Jean
Journal:  Exp Brain Res       Date:  1990       Impact factor: 1.972

6.  A quantitative pharmacological analysis of some excitatory amino acid receptors in the mouse neocortex in vitro.

Authors:  N R Burton; D A Smith; T W Stone
Journal:  Br J Pharmacol       Date:  1988-03       Impact factor: 8.739
  6 in total

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