Literature DB >> 6145935

Modification of the haemoglobin oxygen dissociation curve in whole blood by a compound with dual action.

R M Hyde, D J Livingstone, R A Patterson, J F Batchelor, W R King.   

Abstract

2-Ethoxy-6-(5-tetrazolyl)xanthone reduces the oxygen affinity of blood by two mechanisms; firstly, by a direct effect on the haemoglobin molecule and secondly by maintaining levels of 2,3-diphosphoglycerate (DPG) in stored blood. This compound thus has potential as a blood storage additive which will improve the oxygen delivery of stored blood.

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Year:  1984        PMID： 6145935     DOI： 10.1016/s0140-6736(84)92000-2

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  2 in total

1.  Oxidative effects of gemfibrozil on anion influx and metabolism in normal and Beta-thalassemic erythrocytes: physiological implications.

Authors:  Ester Tellone; Silvana Ficarra; Bruno Giardina; Roberto Scatena; Annamaria Russo; M Elisabetta Clementi; Francesco Misiti; Ersilia Bellocco; Antonio Galtieri
Journal:  J Membr Biol       Date:  2008-09-29       Impact factor: 1.843

2.  Effects of gemfibrozil on the oxygen transport properties of erythrocytes.

Authors:  R Scatena; G Nocca; I Messana; P De Sole; S Baroni; C Zuppi; M Castagnola; B Giardina
Journal:  Br J Clin Pharmacol       Date:  1995-01       Impact factor: 4.335
  2 in total

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