| Literature DB >> 6145781 |
V Petrow, G M Padilla, S Mukherji, S A Marts.
Abstract
Growth of the Dunning R3327-H prostatic adenocarcinoma, implanted in the rat, is inhibited by 6-methylene progesterone. This compound is a potent inhibitor of rat prostatic 5-alpha-reductase and in-vivo produced marked involution of the prostate. Thus the tumor requires dihydrotestosterone and not testosterone for growth.Entities:
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Year: 1984 PMID： 6145781 DOI： 10.1111/j.2042-7158.1984.tb04395.x
Source DB: PubMed Journal: J Pharm Pharmacol ISSN： 0022-3573 Impact factor: 3.765