Parental transmission in Huntington's disease.

There have been reports that juvenile onset Huntington's chorea is almost always inherited from the father, and that late-onset Huntington's chorea is inherited more often from the mother than from the father. In this larger survey of the parental transmission of disease in Huntington chorea 12 of 13 patients whose symptoms began before the age of 10 years had inherited the disease from the father. However, the 205 patients with late-onset disease (those who had lived up to at least the age of 65) were as likely to have inherited their disease from their father as from their mother.