Literature DB >> 6144724

The effect of neuroleptic treatment and of high dosage diazepam therapy on beta-endorphin immunoreactivity in plasma of schizophrenic patients.

C Gramsch, H M Emrich, S John, S Haas, H Beckmann, M Zaudig, D von Zerssen.   

Abstract

In 14 schizophrenic patients, treated with neuroleptic drugs, and in 7 patients, treated with high-dosage diazepam, beta-endorphin-like immunoreactivity in plasma has been measured by use of a highly sensitive and relatively specific radioimmunoassay. Neuroleptic treatment induced a significant increase of beta-endorphin-like immunoreactivity (beta-ELI). The pharmacological and clinical implications of this finding are discussed. High-dosage diazepam treatment induces a slight reduction of plasma beta-ELI, a finding which is attributed to antistress effect of diazepam.

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Year:  1984        PMID： 6144724     DOI： 10.1007/bf01255411

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  15 in total

1.  beta-Endorphin, cortisol, and prolactin in serum of schizophrenic patients during long-term neuroleptic treatment and after withdrawal: relationships to psychopathology.

Authors:  D Naber; M Albus; F Muller; H Burke; D Welter; M Ackenheil; H Hippius
Journal:  Psychopharmacol Bull       Date:  1982-10

2.  Anxiolytic properties of opiates and endogenous opioid peptides and their relationship to the actions of benzodiazepines.

Authors:  M J Millan; T Duka
Journal:  Mod Probl Pharmacopsychiatry       Date:  1981

3.  Plasma levels of beta-endorphin under chronic neuroleptic treatment in schizophrenic patients: failure of naloxone to counteract curative effects of neuroleptic drugs.

Authors:  H M Emrich; V Höllt; M Bergmann; W Kissling; W Schmid; D V Zerssen; A Herz
Journal:  Adv Biochem Psychopharmacol       Date:  1980

4.  beta-Endorphin-like immunoreactivity in cerebrospinal fluid and plasma of patients with schizophrenia and other neuropsychiatric disorders.

Authors:  H M Emrich; V Höllt; W Kissling; M Fischler; H Laspe; H Heinemann; D von Zerssen; A Herz
Journal:  Pharmakopsychiatr Neuropsychopharmakol       Date:  1979-05

5.  Increased CSF levels of endorphines in chronic psychosis.

Authors:  L Terenius; A Wahlström; L Lindström; E Widerlöv
Journal:  Neurosci Lett       Date:  1976-10       Impact factor: 3.046

6.  Rapid changes in enkephalin levels in rat striatum and hypothalamus induced by diazepam.

Authors:  T Duka; M Wüster; A Herz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-10       Impact factor: 3.000

7.  Analgesic and euphoric effects of high dose diazepam in schizophrenia.

Authors:  S Haas; H M Emrich; H Beckmann
Journal:  Neuropsychobiology       Date:  1982       Impact factor: 2.328

8.  Endogenous opioid activity and beta-endorphin immunoreactivity in CSF of psychiatric patients and normal volunteers.

Authors:  D Naber; D Pickar; R M Post; D P Van Kammen; R N Waters; J C Ballenger; F K Goodwin; W E Bunney
Journal:  Am J Psychiatry       Date:  1981-11       Impact factor: 18.112

9.  Long-term treatment of rats with morphine reduces the activity of messenger ribonucleic acid coding for the beta-endorphin/ACTH precursor in the intermediate pituitary.

Authors:  V Höllt; I Haarmann; A Herz
Journal:  J Neurochem       Date:  1981-09       Impact factor: 5.372

10.  High dose diazepam in schizophrenia.

Authors:  H Beckmann; S Haas
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530
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