Literature DB >> 6144708

Phenotypic heterogeneity of antisyngeneic tumor killer cells (ASTK) generated in allogeneic mixed lymphocyte reactions.

S Macphail, P A Paciucci, O Stutman.   

Abstract

By using monoclonal antibodies to Thy-1, Lyt-2, and Qa-5 differentiation antigens, we demonstrated a heterogeneity of cytotoxic cells developed in allogeneic mixed lymphocyte responses that lyse tumor cells syngeneic with the responder cells. There are minimally two Thy-1+ populations, one of which is Lyt-2+ and the other Lyt-2-. There is probably also a Thy-1- population. Most of the Lyt-2- tumor killer cells are Qa-5+, and most of the Lyt-2+ tumor killer cells are Qa-5-.

Entities:  

Mesh:

Substances:

Year:  1984        PMID: 6144708

Source DB:  PubMed          Journal:  J Immunol        ISSN: 0022-1767            Impact factor:   5.422


  7 in total

1.  Pronounced antitumor effect of LAK-like cells induced in the peritoneal cavity of mice after intraperitoneal injection of OK-432, a killed streptococcal preparation.

Authors:  M Saito; O Ichimura; M Kataoka; Y Moriya; K Ueno; Y Sugawara; M Nanjo; N Ishida
Journal:  Cancer Immunol Immunother       Date:  1986       Impact factor: 6.968

2.  Natural cytotoxic (NC) activity: a multi-lineage system regulated by IL-2.

Authors:  E C Lattime; M J Bykowsky; O Stutman
Journal:  Immunol Res       Date:  1986       Impact factor: 2.829

3.  Heterogeneous cytotoxic cells that kill NC-sensitive WEHI-164 tumor cells are activated in allogeneic mixed lymphocyte reactions.

Authors:  S Macphail; O Stutman
Journal:  Immunol Res       Date:  1986       Impact factor: 2.829

4.  Anti-L3T4 antibody inhibits the lysis of H-2 class II antigen-negative target cells by L3T4+ cytotoxic T lymphocytes.

Authors:  S Macphail; O Stutman
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

5.  Adoptive immunotherapy of a BALB/c lymphoma by syngeneic anti-DBA/2 immune lymphoid cells: characterization of the effector population and evidence for the role of the host's non-T cells.

Authors:  M P Colombo; M Parenza; G Parmiani
Journal:  Cancer Immunol Immunother       Date:  1985       Impact factor: 6.968

6.  H-2-linked genes determine the level of the primary in vitro anti-Mls response.

Authors:  S Macphail; O Stutman
Journal:  Immunogenetics       Date:  1986       Impact factor: 2.846

7.  Allostimulation of patients' lymphocytes generates both T and NK-like cells cytotoxic for autologous melanoma.

Authors:  A Balsari; G Fossati; D Taramelli; G Tona; D Delia; R Giardini; G Parmiani
Journal:  Br J Cancer       Date:  1985-07       Impact factor: 7.640

  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.