Literature DB >> 6144341

Effects of sea-anemone toxin (ATX-II) on the frequency of miniature endplate potentials at rat neuromuscular junctions.

J B Harris, I Tesseraux.   

Abstract

Soleus and extensor digitorum longus muscles were isolated from rats. The muscles were exposed to ATX-II, a toxin isolated from extracts of the sea-anemone Anemonia sulcata . The toxin caused a dose-dependent increase in the frequency of miniature endplate potentials in both types of muscle. The increase in frequency could be reversed by the application of tetrodotoxin (TTX), and could be prevented by prior exposure of the muscles to TTX. It is concluded that ATX-II causes a sodium-dependent depolarization of the nerve-terminal membrane.

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Year:  1984        PMID： 6144341      PMCID： PMC1986903          DOI： 10.1111/j.1476-5381.1984.tb16120.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  6 in total

1.  Decreased rate of sodium conductance inactivation in the node of Ranvier induced by a polypeptide toxin from sea anemone.

Authors:  C Bergman; J M Dubois; E Rojas; W Rathmayer
Journal:  Biochim Biophys Acta       Date:  1976-11-11

2.  Sea anemone toxin:a tool to study molecular mechanisms of nerve conduction and excitation-secretion coupling.

Authors:  G Romey; J P Abita; H Schweitz; G Wunderer
Journal:  Proc Natl Acad Sci U S A       Date:  1976-11       Impact factor: 11.205

3.  Purification of three polypeptides with neuro- and cardiotoxic activity from the sea anemone Anemonia sulcata.

Authors:  L Béress; R Béress
Journal:  Toxicon       Date:  1975-11       Impact factor: 3.033

4.  The pharmacology of batrachotoxin. II. Effect on electrical properties of the mammalian nerve and skeletal muscle membranes.

Authors:  E X Albuquerque; J E Warnick; F M Sansone
Journal:  J Pharmacol Exp Ther       Date:  1971-03       Impact factor: 4.030

5.  Mechanical and electrophysiological effects of sea anemone (Anemonia sulcata) toxins on rat innervated and denervated skeletal muscle.

Authors:  C Alsen; J B Harris; I Tesseraux
Journal:  Br J Pharmacol       Date:  1981-09       Impact factor: 8.739

6.  Effects of neurotoxins (veratridine, sea anemone toxin, tetrodotoxin) on transmitter accumulation and release by nerve terminals in vitro.

Authors:  J P Abita; R Chicheportiche; H Schweitz; M Lazdunski
Journal:  Biochemistry       Date:  1977-05-03       Impact factor: 3.162
  6 in total
  1 in total

1.  Ciguatoxin enhances quantal transmitter release from frog motor nerve terminals.

Authors:  J Molgó; J X Comella; A M Legrand
Journal:  Br J Pharmacol       Date:  1990-04       Impact factor: 8.739
  1 in total

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