The influence of modified sham feeding on plasma polypeptide (CCK, gastrin, motilin, neurotensin and somatostatin) concentrations in duodenal ulcer disease.

Changes in gastric acid secretion and plasma levels of CCK, gastrin, motilin, neurotensin and somatostatin in response to modified sham feeding (MSF) were investigated in 8 asymptomatic duodenal ulcer patients. MSF caused a significant increase in gastric acid secretion whereas the peripheral plasma concentrations of the various polypeptides remained unchanged. The study gives further support for the notion that MSF activates the vagal innervation to the parietal cells more selectively than insulin hypoglycaemia.