| Literature DB >> 61440 |
R H Purcell, W T London, V J McAuliffe, A E Palmer, P M Kaplan, J L Gerin, J Wagner, H Popper, E Lvovsky, D C Wong, H B Levy.
Abstract
Chimpanzees chronically infected with hepatitis-B virus showed transient changes in several markers of infection when treated with the interferon inducer polyriboinosinic-polyribocytidylic acid-poly-l-lysine carboxymethyl cellulose. Serum Dane-particle-associated D.N.A. polymerase, e antigen and hepatitis-B surface antigen, and intrahepatic hepatitis-B surface and core antigens diminished during treatment. Defective (D.N.A.-polymerase-negative) Dane particles increased in titre transiently during treatment; these may play a role in the modulation of hepatitis-B virus infection. Humoral immune responses in chronic hepatitis-B carrier chimps were unaffected. Interferon inducers (or exogenous interferon) may be useful for the treatment of chronic hepatitis-B virus infection.Entities:
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Year: 1976 PMID： 61440 DOI： 10.1016/s0140-6736(76)90598-5
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321