| Literature DB >> 6143975 |
A Schonfeld, S Nitke, A Schattner, D Wallach, M Crespi, T Hahn, H Levavi, O Yarden, J Shoham, T Doerner.
Abstract
A two-part study was done to assess the value of human fibroblast interferon (IFN-beta) in the treatment of condylomata acuminata. The first part was an open study of different IFN-beta preparations, which showed that intramuscular injection was the most suitable mode of administration of IFN-beta. In the double-blind placebo section 22 patients were given injections of 2 X 10(6) units IFN-beta or placebo for 10 consecutive days and followed up for 3 months. In 9 of the 11 in the IFN-beta group and 2 in the placebo group lesions disappeared from about 5 weeks after completion of the course of injections. After 3 months 8 of the non-responders were given a course of IFN-beta and all responded to treatment. None of those who had responded has had a recurrence, the disease-free period now being 12 months. Changes in (2'-5')oligo A synthetase levels in white blood cells confirm that intramuscular injections of IFN-beta produce a systemic response.Entities:
Mesh：
Substances：
Year: 1984 PMID： 6143975 DOI： 10.1016/s0140-6736(84)91450-8
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321