Literature DB >> 6143794

On the substrate specificities of the two forms of monoamine oxidase.

C J Fowler, K F Tipton.   

Abstract

By use of the selective irreversible inhibitors clorgyline and selegiline [(-)-deprenyl], it is possible to determine the Km and Vmax values of the two forms of monoamine oxidase towards a variety of substrates. The validity of this procedure is demonstrated for the deamination of dopamine by rat liver monoamine oxidase -A and -B, and the specificities of the two forms are analysed in terms of their kinetic parameters towards different substrates.

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Year:  1984        PMID： 6143794     DOI： 10.1111/j.2042-7158.1984.tb03004.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  16 in total

1.  Expression of monoamine oxidase B activity in astrocytes of senile plaques.

Authors:  S Nakamura; T Kawamata; I Akiguchi; M Kameyama; N Nakamura; H Kimura
Journal:  Acta Neuropathol       Date:  1990       Impact factor: 17.088

2.  Molecular determinants in the bioactivation of the dopaminergic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

Authors:  S M Efange; R J Boudreau
Journal:  J Comput Aided Mol Des       Date:  1991-10       Impact factor: 3.686

3.  Effect of monoamine oxidase A and B and of catechol-O-methyltransferase inhibition on L-DOPA-induced circling behavior.

Authors:  M J Heeringa; F d'Agostini; P DeBoer; M DaPrada; G Damsma
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

4.  Monoamine oxidase B inhibition reduces gastric mucosal blood flow, basal acid secretion, and cold water restraint-induced gastric mucosal injury in rats.

Authors:  L P Xing; J Washington; J Seaton; G Kauffman
Journal:  Dig Dis Sci       Date:  1990-01       Impact factor: 3.199

5.  Androgen metabolites impact CSF amines and axonal serotonin via MAO-A and -B in male macaques.

Authors:  C L Bethea; K Phu; A Kim; A P Reddy
Journal:  Neuroscience       Date:  2015-06-16       Impact factor: 3.590

6.  A kinetic investigation of the pulmonary metabolism of dopamine in rats shows marked differences compared with noradrenaline.

Authors:  D L Scarcella; L J Bryan-Lluka
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-05       Impact factor: 3.000

7.  Role of monoamine oxidase type A and B on the dopamine metabolism in discrete regions of the primate brain.

Authors:  M K Lakshmana; B S Rao; N K Dhingra; R Ravikumar; S Sudha; B L Meti; T R Raju
Journal:  Neurochem Res       Date:  1998-08       Impact factor: 3.996

8.  Monoamine oxidase inhibition by L-deprenyl depends on both sex and route of administration in the rat.

Authors:  M P Murphy; P H Wu; N W Milgram; G O Ivy
Journal:  Neurochem Res       Date:  1993-12       Impact factor: 3.996

9.  Histochemistry of MAO-A and MAO-B in the locus coeruleus of the Mongolian gerbil.

Authors:  C Konradi; K Jellinger; P Riederer; T Nagatsu
Journal:  J Neural Transm       Date:  1987       Impact factor: 3.575

10.  Inhibition of monoamine oxidase and semicarbazide-sensitive amine oxidase by mexiletine and related compounds.

Authors:  M Eriksson; C J Fowler
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-10       Impact factor: 3.000
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