| Literature DB >> 6142994 |
R Yomtovian, W Kline, C Press, M Clay, H Engman, D Hammerschmidt, J McCullough.
Abstract
A life-threatening pulmonary hypersensitivity reaction accompanied by profound leucopenia and transient hypocomplementaemia developed in a 73-year-old man after repair of an abdominal aortic aneurysm. A neutrophil-specific antibody, anti-NA2) was demonstrated by granulocyte immunofluorescence and microagglutination in one of the transfused donor units. In addition, activated complement component C5a was generated in vitro by incubation of the patient's serum with the aortic graft material. This severe clinical reaction may have resulted from the interaction of the transfused anti-NA2 antibody with complement activation induced by the aortic graft material.Entities:
Mesh：
Substances：
Year: 1984 PMID： 6142994 DOI： 10.1016/s0140-6736(84)90124-7
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321