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Literature DB >> 6142863

Role of pili in the adherence of Pseudomonas aeruginosa to injured tracheal epithelium.

R Ramphal, J C Sadoff, M Pyle, J D Silipigni.

Abstract

Pili have been demonstrated to be the adhesins of nonmucoid Pseudomonas aeruginosa for buccal cells. In this study, we examined their role in the adherence of both mucoid and nonmucoid strains to injured tracheal cells. Pili incubated with tracheal cells inhibited the adherence of a nonmucoid strain in a dose-dependent manner. Both homologous and heterologous pili inhibited this nonmucoid strain. Antibody against pili from the nonmucoid strain inhibited adherence of the homologous but not a heterologous strain. Pili failed to inhibit two mucoid strains, but inhibited nonmucoid variants derived from mucoid strains. These studies suggest that pili mediate the adherence of nonmucoid strains to injured tracheal cells but that they are not the final mediators of adherence of mucoid strains. It is also inferred that there are differences in the receptor for mucoid and nonmucoid strains.

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Substances：
Hydrochloric Acid

Year: 1984 PMID： 6142863 PMCID： PMC263463 DOI： 10.1128/iai.44.1.38-40.1984

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

8 in total

1. Adherence of Escherichia coli to human mucosal cells mediated by mannose receptors.

Authors: I Ofek; D Mirelman; N Sharon
Journal: Nature Date: 1977-02-17 Impact factor: 49.962

Review 2. The role of bacterial surface structures in pathogenesis.

Authors: J W Costerton; R T Irvin; K J Cheng
Journal: Crit Rev Microbiol Date: 1981 Impact factor: 7.624

3. Analysis of parameters affecting the solid phase radioimmunoassay quantitation of antibody to meningococcal antigens.

Authors: W D Zollinger; J M Dalrymple; M S Artenstein
Journal: J Immunol Date: 1976-11 Impact factor: 5.422

4. Adherence of Pseudomonas aeruginosa to tracheal cells injured by influenza infection or by endotracheal intubation.

Authors: R Ramphal; P M Small; J W Shands; W Fischlschweiger; P A Small
Journal: Infect Immun Date: 1980-02 Impact factor: 3.441

5. Role of adherence in the pathogenesis of Pseudomonas aeruginosa lung infection in cystic fibrosis patients.

Authors: D E Woods; J A Bass; W G Johanson; D C Straus
Journal: Infect Immun Date: 1980-12 Impact factor: 3.441

6. Adherence of mucoid and nonmucoid Pseudomonas aeruginosa to acid-injured tracheal epithelium.

Authors: R Ramphal; M Pyle
Journal: Infect Immun Date: 1983-07 Impact factor: 3.441

7. Role of pili in adherence of Pseudomonas aeruginosa to mammalian buccal epithelial cells.

Authors: D E Woods; D C Straus; W G Johanson; V K Berry; J A Bass
Journal: Infect Immun Date: 1980-09 Impact factor: 3.441

8. Evidence for mucins and sialic acid as receptors for Pseudomonas aeruginosa in the lower respiratory tract.

Authors: R Ramphal; M Pyle
Journal: Infect Immun Date: 1983-07 Impact factor: 3.441

8 in total

57 in total

7. Evidence that in vitro adherence of Klebsiella pneumoniae to ciliated hamster tracheal cells is mediated by type 1 fimbriae.

Authors: R C Fader; K Gondesen; B Tolley; D G Ritchie; P Moller
Journal: Infect Immun Date: 1988-11 Impact factor: 3.441

8. Human tracheobronchial mucin: purification and binding to Pseudomonas aeruginosa.

Authors: M S Reddy
Journal: Infect Immun Date: 1992-04 Impact factor: 3.441

9. The pilG gene product, required for Pseudomonas aeruginosa pilus production and twitching motility, is homologous to the enteric, single-domain response regulator CheY.

Authors: A Darzins
Journal: J Bacteriol Date: 1993-09 Impact factor: 3.490

10. Pseudomonas aeruginosa pili bind to asialoGM1 which is increased on the surface of cystic fibrosis epithelial cells.

Authors: L Saiman; A Prince
Journal: J Clin Invest Date: 1993-10 Impact factor: 14.808

Role of pili in the adherence of Pseudomonas aeruginosa to injured tracheal epithelium.

1. Adherence of Escherichia coli to human mucosal cells mediated by mannose receptors.

Review 2. The role of bacterial surface structures in pathogenesis.

3. Analysis of parameters affecting the solid phase radioimmunoassay quantitation of antibody to meningococcal antigens.

4. Adherence of Pseudomonas aeruginosa to tracheal cells injured by influenza infection or by endotracheal intubation.

5. Role of adherence in the pathogenesis of Pseudomonas aeruginosa lung infection in cystic fibrosis patients.

6. Adherence of mucoid and nonmucoid Pseudomonas aeruginosa to acid-injured tracheal epithelium.

7. Role of pili in adherence of Pseudomonas aeruginosa to mammalian buccal epithelial cells.

8. Evidence for mucins and sialic acid as receptors for Pseudomonas aeruginosa in the lower respiratory tract.

Review 1. Recognition of mucin components by Pseudomonas aeruginosa.

2. Severe gastroparesis causing postoperative respiratory complications in a heart-lung recipient.

Review 3. Pathogenesis and management of lung disease in cystic fibrosis.

4. Cross-reactive and strain-specific antipeptide antibodies to Pseudomonas aeruginosa PAK and PAO pili.

Review 5. Lung infections. 3. Pseudomonas aeruginosa and other related species.

6. Influence of pilin glycosylation on Pseudomonas aeruginosa 1244 pilus function.

7. Evidence that in vitro adherence of Klebsiella pneumoniae to ciliated hamster tracheal cells is mediated by type 1 fimbriae.

8. Human tracheobronchial mucin: purification and binding to Pseudomonas aeruginosa.

9. The pilG gene product, required for Pseudomonas aeruginosa pilus production and twitching motility, is homologous to the enteric, single-domain response regulator CheY.

10. Pseudomonas aeruginosa pili bind to asialoGM1 which is increased on the surface of cystic fibrosis epithelial cells.