Literature DB >> 6142307

Altered transcription of an oncogene in chronic myeloid leukaemia.

E Canaani, R P Gale, D Steiner-Saltz, A Berrebi, E Aghai, E Januszewicz.   

Abstract

The oncogene abl, which resides on chromosome 9, is translocated to chromosome 22 as part of the Philadelphia (Ph1) chromosome. Leukaemic cells from 5 of 6 patients with chronic myelogenous leukaemia (CML) and the Ph1 chromosome were found to contain a new 8 kb abl RNA transcript. This finding raises the possibility that the abl oncogene is directly involved in the development of CML. It is suggested that the abl gene's expression is altered by the DNA rearrangement in the translocation.

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Year:  1984        PMID： 6142307     DOI： 10.1016/s0140-6736(84)90997-8

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  23 in total

Review 1.  Molecular analysis of the Philadelphia chromosome.

Authors:  A Dobrovic; G B Peters; J H Ford
Journal:  Chromosoma       Date:  1991-09       Impact factor: 4.316

2.  Translocation of oncogene c-sis from chromosome 22 to chromosome 11 in a Ewing sarcoma-derived cell line.

Authors:  A G van Kessel; C Turc-Carel; A de Klein; G Grosveld; G Lenoir; D Bootsma
Journal:  Mol Cell Biol       Date:  1985-02       Impact factor: 4.272

3.  v-abl activates embryonic globin gene expression in mouse erythroleukemia cells.

Authors:  A R Lopez; J Barker; A B Deisseroth
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

4.  Cell lines and peripheral blood leukocytes derived from individuals with chronic myelogenous leukemia display virtually identical proteins phosphorylated on tyrosine residues.

Authors:  R D Huhn; M R Posner; S I Rayter; J G Foulkes; A R Frackelton
Journal:  Proc Natl Acad Sci U S A       Date:  1987-07       Impact factor: 11.205

Review 5.  Molecular and cellular bases of chronic myeloid leukemia.

Authors:  Yaoyu Chen; Cong Peng; Dongguang Li; Shaoguang Li
Journal:  Protein Cell       Date:  2010-02-06       Impact factor: 14.870

6.  Expression of bcr and bcr-abl fusion transcripts in normal and leukemic cells.

Authors:  S Collins; H Coleman; M Groudine
Journal:  Mol Cell Biol       Date:  1987-08       Impact factor: 4.272

Review 7.  Diagnosis and Treatment of Chronic Myeloid Leukemia in 2015.

Authors:  Philip A Thompson; Hagop M Kantarjian; Jorge E Cortes
Journal:  Mayo Clin Proc       Date:  2015-10       Impact factor: 7.616

8.  Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome.

Authors:  A M Mes-Masson; J McLaughlin; G Q Daley; M Paskind; O N Witte
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

9.  Reciprocal translocation between chromosomes 8 and 9 in atypical chronic myeloid leukaemia.

Authors:  D G Oscier; G J Mufti; A Gardiner; T J Hamblin
Journal:  J Med Genet       Date:  1985-10       Impact factor: 6.318

10.  An 8-kilobase abl RNA transcript in chronic myelogenous leukemia.

Authors:  R P Gale; E Canaani
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205
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