Literature DB >> 6142255

Absence of monoclonal-antibody-defined protein complex in boy with abnormal leucocyte function.

P G Beatty, H D Ochs, J M Harlan, T H Price, H Rosen, R F Taylor, J A Hansen, S J Klebanoff.   

Abstract

An 8-year-old boy with severe recurrent bacterial infections was found to lack the cell-surface multimeric polypeptide complex defined by murine monoclonal antibody 60.3. This complex is expressed on the surface of all normal polymorphonuclear leucocytes (PMN), monocytes, and lymphocytes. Incubation of normal lymphocytes or PMN with antibody 60.3 produced functional abnormalities comparable with those observed in the patient's cells, suggesting that the polypeptide complex plays a significant part in several membrane-dependent leucocyte functions.

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Year:  1984        PMID： 6142255     DOI： 10.1016/s0140-6736(84)90933-4

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  29 in total

1.  Polymorphonuclear leucocytes in Crohn's disease and ulcerative proctocolitis: association between enhanced adherence to nylon fibre and disease variables.

Authors:  J Cason; C C Ainley; R A Wolstencroft; R P Thompson
Journal:  J Clin Pathol       Date:  1988-03       Impact factor: 3.411

2.  T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

Authors:  P S Linsley; E A Clark; J A Ledbetter
Journal:  Proc Natl Acad Sci U S A       Date:  1990-07       Impact factor: 11.205

3.  Defective expression of T cell-associated glycoprotein in severe combined immunodeficiency.

Authors:  L K Jung; S M Fu; T Hara; N Kapoor; R A Good
Journal:  J Clin Invest       Date:  1986-03       Impact factor: 14.808

4.  Absence of complement receptor type 3 and lymphocyte function antigen 1 causing deficient phagocyte and lymphocyte functions.

Authors:  M M Manzionna; R A Seger; V Wahn; R M Zinkernagel; A Böcker; W H Hitzig
Journal:  Eur J Pediatr       Date:  1988-10       Impact factor: 3.183

5.  Role of beta 2 integrins and ICAM-1 in lung injury following ischemia-reperfusion of rat hind limbs.

Authors:  A Seekamp; M S Mulligan; G O Till; C W Smith; M Miyasaka; T Tamatani; R F Todd; P A Ward
Journal:  Am J Pathol       Date:  1993-08       Impact factor: 4.307

6.  LFA-1 immunodeficiency disease. Definition of the genetic defect and chromosomal mapping of alpha and beta subunits of the lymphocyte function-associated antigen 1 (LFA-1) by complementation in hybrid cells.

Authors:  S D Marlin; C C Morton; D C Anderson; T A Springer
Journal:  J Exp Med       Date:  1986-09-01       Impact factor: 14.307

7.  Vectors for the expression of PCR-amplified immunoglobulin variable domains with human constant regions.

Authors:  M A Walls; K C Hsiao; L J Harris
Journal:  Nucleic Acids Res       Date:  1993-06-25       Impact factor: 16.971

8.  Deficiency of a leukocyte surface glycoprotein (LFA-1) in two patients with Mo1 deficiency. Effects of cell activation on Mo1/LFA-1 surface expression in normal and deficient leukocytes.

Authors:  M A Arnaout; H Spits; C Terhorst; J Pitt; R F Todd
Journal:  J Clin Invest       Date:  1984-10       Impact factor: 14.808

9.  Obstructive endocarditis in an immunodeficient infant.

Authors:  M D Walters; J E Deanfield; P J Robinson; D J Matthew
Journal:  Eur J Pediatr       Date:  1986-12       Impact factor: 3.183

10.  Adherence of human basophils to cultured umbilical vein endothelial cells.

Authors:  B S Bochner; P T Peachell; K E Brown; R P Schleimer
Journal:  J Clin Invest       Date:  1988-05       Impact factor: 14.808
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