Literature DB >> 6141983

The mechanism of the histamine-induced desensitization of guinea-pig ileum.

B Bielkiewicz, D A Cook.   

Abstract

Histamine and the selective H1 receptor agonist 2-pyridylethylamine show cross-desensitization when tested in guinea-pig ileum. The H1 receptor blocking agent produces a smaller parallel shift in desensitized tissues when compared with non-desensitized controls. We conclude that desensitization in this system occurs at the receptor level and is reflected by a decreased sensitivity to both agonists and antagonists.

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Year:  1984        PMID： 6141983     DOI： 10.1016/0306-3623(84)90080-6

Source DB:  PubMed          Journal:  Gen Pharmacol        ISSN： 0306-3623


  6 in total

1.  Alterations in histamine receptors of guinea-pig ileal smooth muscle produced during agonist-induced desensitization.

Authors:  S Horio; S Nakamura; Y Ishida
Journal:  Br J Pharmacol       Date:  1990-11       Impact factor: 8.739

2.  Effects of local anaesthetics on short-term desensitization of guinea-pig taenia caecum to histamine.

Authors:  S Hishinuma; M K Uchida
Journal:  Br J Pharmacol       Date:  1987-12       Impact factor: 8.739

3.  Temperature-dependence of desensitization induced by acetylcholine and histamine in guinea-pig ileal longitudinal muscle.

Authors:  S Horio; M Shima; H Ueda; Y Ishida
Journal:  Br J Pharmacol       Date:  1990-07       Impact factor: 8.739

4.  Different profiles of desensitization dynamics in guinea-pig jejunal longitudinal smooth muscle after stimulation with histamine and methacholine.

Authors:  R Leurs; M J Smit; A Bast; H Timmerman
Journal:  Br J Pharmacol       Date:  1990-12       Impact factor: 8.739

5.  Disturbance of the prejunctional modulation of cholinergic neurotransmission during chronic granulomatous inflammation of the mouse ileum.

Authors:  J G De Man; T G Moreels; B Y De Winter; J J Bogers; E A Van Marck; A G Herman; P A Pelckmans
Journal:  Br J Pharmacol       Date:  2001-07       Impact factor: 8.739

6.  Long-term depletion of histamine in guinea-pigs by administration of alpha-fluoromethylhistidine, a specific inhibitor of histidine decarboxylase; effect on the sensitivity of histamine receptors.

Authors:  H Fukuda; K Maeyama; Y Ito; T Watanabe; H Wada
Journal:  Agents Actions       Date:  1988-06
  6 in total

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