Literature DB >> 6141837

Selective dendrite damage in hippocampal CA1 stratum radiatum with unchanged axon ultrastructure and glutamate uptake after transient cerebral ischaemia in the rat.

F F Johansen, M B Jørgensen, D K Ekström von Lubitz, N H Diemer.   

Abstract

In this study of the rat hippocampal CA1 stratum radiatum 4 days after 20 min transient cerebral ischaemia, we demonstrated ultrastructural dendritic degeneration and loss, whereas most axons appeared undamaged. Autoradiographs 4 days after ischaemia showed unchanged Na+-dependent glutamate high affinity uptake. The role of glutamate and Ca2+ for this selective postsynaptic vulnerability is discussed.

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Year:  1984        PMID： 6141837     DOI： 10.1016/0006-8993(84)91272-1

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  19 in total

1.  Selective vulnerability in the gerbil hippocampus: morphological changes after 5-min ischemia and long survival times.

Authors:  P Bonnekoh; A Barbier; U Oschlies; K A Hossmann
Journal:  Acta Neuropathol       Date:  1990       Impact factor: 17.088

2.  Cerebral ischemia: changes in monoamines are independent of energy metabolism.

Authors:  B B Mrsulja; B M Djuricic; Y Ueki; W D Lust; M Spatz
Journal:  Neurochem Res       Date:  1989-01       Impact factor: 3.996

3.  The dentate gyrus in hypoglycemia: pathology implicating excitotoxin-mediated neuronal necrosis.

Authors:  R Auer; H Kalimo; Y Olsson; T Wieloch
Journal:  Acta Neuropathol       Date:  1985       Impact factor: 17.088

4.  Global ischemia induces downregulation of Glur2 mRNA and increases AMPA receptor-mediated Ca2+ influx in hippocampal CA1 neurons of gerbil.

Authors:  J A Gorter; J J Petrozzino; E M Aronica; D M Rosenbaum; T Opitz; M V Bennett; J A Connor; R S Zukin
Journal:  J Neurosci       Date:  1997-08-15       Impact factor: 6.167

5.  Electron microscopic evidence against apoptosis as the mechanism of neuronal death in global ischemia.

Authors:  F Colbourne; G R Sutherland; R N Auer
Journal:  J Neurosci       Date:  1999-06-01       Impact factor: 6.167

6.  Neural grafting to ischemic lesions of the adult rat hippocampus.

Authors:  N Tønder; T Sørensen; J Zimmer; M B Jørgensen; F F Johansen; N H Diemer
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

7.  Metabolic disturbances of synaptosomes isolated from ischemic gerbil brain.

Authors:  K Domańska-Janik; J Lazarewicz; K Noremberg; J Strosznajder; T Zalewska
Journal:  Neurochem Res       Date:  1985-05       Impact factor: 3.996

8.  Temperature effect on immunostaining of microtubule-associated protein 2 and synaptophysin after 30 minutes of forebrain ischemia in rat.

Authors:  T Miyazawa; P Bonnekoh; K A Hossmann
Journal:  Acta Neuropathol       Date:  1993       Impact factor: 17.088

9.  Early axonal lesion and preserved microvasculature in epilepsy-induced hypermetabolic necrosis of the substantia nigra.

Authors:  R N Auer; M Ingvar; G Nevander; Y Olsson; B K Siesjö
Journal:  Acta Neuropathol       Date:  1986       Impact factor: 17.088

Review 10.  Cerebral ischemia revisited: new insights as revealed using in vitro brain slice preparations.

Authors:  A Schurr; B M Rigor
Journal:  Experientia       Date:  1989-08-15
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