Literature DB >> 6141501

Opioid peptides and seizures in the spontaneously epileptic Mongolian gerbil.

R J Lee, J G Bajorek, P Lomax.   

Abstract

The naturally epileptic Mongolian gerbil was used to investigate the epileptogenic properties of beta-endorphin, dynorphin, met-enkephalin and morphine. The results indicate that opioid induced "seizures" are different from naturally spontaneous seizures in the gerbil in respect to EEG recording and motor behavior. Evidence for a protective role in preventing seizures is also presented.

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Year:  1983        PMID： 6141501     DOI： 10.1016/0024-3205(83)90566-0

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  4 in total

Review 1.  Central non-opioid physiological and pathophysiological effects of dynorphin A and related peptides.

Authors:  V K Shukla; S Lemaire
Journal:  J Psychiatry Neurosci       Date:  1992-09       Impact factor: 6.186

2.  Endogenous methionine enkephalin may play an anticonvulsant role in the seizure-susceptible El mouse.

Authors:  S Koide; H Onishi; M Katayama; S Yamagami
Journal:  Neurochem Res       Date:  1993-12       Impact factor: 3.996

3.  Effects of morphine and D-Ala2-D-Leu5-enkephalin in the seizure-susceptible El mouse.

Authors:  S Koide; H Onishi; S Yamagami; Y Kawakita
Journal:  Neurochem Res       Date:  1992-08       Impact factor: 3.996

4.  The opioid antagonist naltrexone decreases seizure-like activity in genetic and chemically induced epilepsy models.

Authors:  Morgan L Sturgeon; Rachel Langton; Shaunik Sharma; Robert A Cornell; Joseph Glykys; Alexander G Bassuk
Journal:  Epilepsia Open       Date:  2021-06-09
  4 in total

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