In-vitro fertilisation of oocytes from women with serum antisperm antibodies.

Five women whose infertility was believed to be related primarily to their serum antisperm antibodies underwent in-vitro fertilisation and embryo transfer. Follicle growth was stimulated with clomiphene citrate, sometimes combined with human menopausal gonadotropin, and ovulation was triggered off with human chorionic gonadotropin. 20 oocytes were collected from the five patients, and 15 of these were fertilised in the presence of donor serum. All embryos developed to morphologically normal 2-cell and 4-cell embryos. All five women proceeded to embryo transfer, and two became pregnant.