Literature DB >> 6141145

Experimental asthma in guinea pigs revisited.

P Kallós, L Kallós.   

Abstract

Experimental asthma in guinea pigs, as defined in 1937 by Kallós and Pagel, and the pertinent literature are reviewed. The relation between guinea pig asthma and human asthma bronchiale is established. The underlying mechanism in both processes is the misdirected (aberrant) formation of anaphylactic or reaginic (IgE) antibody against innocuous antigens, leading at renewed exposure to the antigen to release of mast cell mediators (such as histamine, SRS-A, eosinotactic peptides, PAF), bronchoconstriction, vasodilation and eosinophilic inflammation at the sites of antigen-antibody reactions in the tissues of the respiratory organs.

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Year:  1984        PMID： 6141145     DOI： 10.1159/000233441

Source DB:  PubMed          Journal:  Int Arch Allergy Appl Immunol        ISSN： 0020-5915


  18 in total

1.  Mechanism of adenosine-induced airways obstruction in allergic guinea pigs.

Authors:  Sandra Keir; Victoria Boswell-Smith; Domenico Spina; Clive Page
Journal:  Br J Pharmacol       Date:  2006-04       Impact factor: 8.739

2.  Regulation of cyclic AMP levels in alveolar macrophages of guinea pigs and man by prostanoids and beta-adrenergic agents.

Authors:  F D Beusenberg; M J Adolfs; J M van Schaik-van Groningen; H C Hoogsteden; I L Bonta
Journal:  Agents Actions       Date:  1989-01

3.  Pharmacological modulation of bronchial anaphylaxis induced by aerosol challenge in anaesthetized guinea-pigs.

Authors:  L Daffonchio; I W Lees; A N Payne; B J Whittle
Journal:  Br J Pharmacol       Date:  1987-07       Impact factor: 8.739

4.  Comparison of the airways relaxant and hypotensive potencies of the potassium channel activators BRL 55834 and levcromakalim (BRL 38227) in vivo in guinea-pigs and rats.

Authors:  N E Bowring; J R Arch; D R Buckle; J F Taylor
Journal:  Br J Pharmacol       Date:  1993-08       Impact factor: 8.739

5.  Inflammatory mediators and cellular infiltration of the lungs in a guinea pig model of the late asthmatic reaction.

Authors:  A F Walls; Y K Rhee; D J Gould; C Walters; C Robinson; M K Church; S T Holgate
Journal:  Lung       Date:  1991       Impact factor: 2.584

6.  Antigen challenge induces pulmonary airway eosinophil accumulation and airway hyperreactivity in sensitized guinea-pigs: the effect of anti-asthma drugs.

Authors:  S Sanjar; S Aoki; A Kristersson; D Smith; J Morley
Journal:  Br J Pharmacol       Date:  1990-04       Impact factor: 8.739

7.  Effect of human recombinant interleukin-5 on in vitro responsiveness to PAF of lung from actively sensitized guinea-pigs.

Authors:  M Pretolani; J Lefort; D Leduc; B B Vargaftig
Journal:  Br J Pharmacol       Date:  1992-07       Impact factor: 8.739

8.  Induction of lung eosinophilia and neutrophilia in guinea pigs following injection of sephadex beads.

Authors:  K Maghni; F Blanchette; P Sirois
Journal:  Inflammation       Date:  1993-10       Impact factor: 4.092

9.  Immediate anaphylactic bronchoconstriction induces airway hyperreactivity in anaesthetized guinea-pigs.

Authors:  L Daffonchio; A N Payne; I W Lees; B J Whittle
Journal:  Br J Pharmacol       Date:  1988-07       Impact factor: 8.739

10.  Pharmacological characterization of mediators and vagal influence in the acute allergic bronchoconstriction in guinea pigs.

Authors:  M H Vargas; L M Montaño; B Vanda; P Segura; M Selman
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-09       Impact factor: 3.000
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