Epidemiologic observations on the relationship between calcium intake and eclampsia.

In Guatemala, the obstetric population has a very low incidence of eclampsia despite the presence of factors that would be expected to favor appearance of the disease. In this study, the eclampsia incidence and calcium intake for three countries, Guatemala (low eclampsia incidence, high calcium intake); Cali, Colombia (high eclampsia incidence, low calcium intake); and the USA (low eclampsia incidence, high calcium intake) have been compared. Crude rates for eclampsia incidence were adjusted to control the effects of well-documented predisposing factors: age, parity, and prenatal care. Results of the study support an association between calcium intake and development of eclampsia.