Literature DB >> 6141059

Antagonism by tetrahydro-beta-carboline of the vasoconstrictor responses to tryptamine in rat tail arteries.

P E Hicks, S Z Langer.   

Abstract

Tryptamine and 5-HT mediate vasoconstriction in the isolated perfused rat tail artery. These agonists were differentiated by the classical serotonin receptor antagonists methysergide and ketanserin which were significantly more potent against 5-HT-induced responses. Neither prazosin nor RX 781094 alone or in combination reduced the vasoconstriction produced by tryptamine. Tetrahydro-beta-carboline (THBC) was devoid of agonist properties and behaved as a competitive antagonist of tryptamine but not of 5-HT. THBC also had alpha-adrenoceptor blocking properties in this preparation.

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Year:  1983        PMID： 6141059     DOI： 10.1016/0014-2999(83)90543-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  5-HT1-like and 5-HT2A receptors mediate 5-hydroxytryptamine-induced contraction of rabbit isolated mesenteric artery.

Authors:  O Yildiz; M Tuncer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-08       Impact factor: 3.000

2.  Effects of tryptamine mediated through 2 states of the 5-HT2 receptor in calf coronary artery.

Authors:  M Frenken; A J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-05       Impact factor: 3.000

3.  Tryptamine-induced vasoconstrictor responses in rat caudal arteries are mediated predominantly via 5-hydroxytryptamine receptors.

Authors:  P B Bradley; P P Humphrey; R H Williams
Journal:  Br J Pharmacol       Date:  1985-04       Impact factor: 8.739

4.  Peripheral 5-HT2-like receptors. Can they be classified with the available antagonists?

Authors:  P Leff; G R Martin
Journal:  Br J Pharmacol       Date:  1986-07       Impact factor: 8.739

5.  Vasoconstrictor and vasodilator responses to tryptamine of rat-isolated perfused mesentery: comparison with tyramine and β-phenylethylamine.

Authors:  M A Anwar; W R Ford; K J Broadley; A A Herbert
Journal:  Br J Pharmacol       Date:  2012-04       Impact factor: 8.739

6.  Signal transduction and modulating pathways in tryptamine-evoked vasopressor responses of the rat isolated perfused mesenteric bed.

Authors:  M Akhtar Anwar; William R Ford; Amy A Herbert; Kenneth J Broadley
Journal:  Vascul Pharmacol       Date:  2012-10-30       Impact factor: 5.773
  6 in total

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