Literature DB >> 6140989

Preferential glutamine uptake by cochlear hair cells: implications for the afferent cochlear transmitter.

A F Ryan, I R Schwartz.   

Abstract

The cochlear uptake of amino acids which are putative neurotransmitters, or closely-related compounds, was examined autoradiographically in the gerbil. Hair cells showed no preferential uptake of most compounds tested. However, preferential accumulation of glutamine by cochlear hair cells was striking. Vestibular hair cells showed no affinity for this amino acid. Glutamine uptake by cochlear hair cells may play an important role in afferent synaptic transmission, by providing transmitter precursor and/or by clearing the synaptic cleft.

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Year:  1984        PMID： 6140989     DOI： 10.1016/0006-8993(84)90960-0

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  4 in total

1.  Immunocytochemical detection of peptides in the guinea pig cochlea.

Authors:  R Nowak; A Dorn; H G Bernstein; A Rinne; H J Scholtz; M Ziegler
Journal:  Arch Otorhinolaryngol       Date:  1986

2.  Activation of glutamate receptors in response to membrane depolarization of hair cells isolated from chick cochlea.

Authors:  Y Kataoka; H Ohmori
Journal:  J Physiol       Date:  1994-06-15       Impact factor: 5.182

3.  Distribution of glutamate-like and glutamine-like immunoreactivities in the rat organ of Corti: a light microscopic and semiquantitative electron microscopic analysis with a note on the localization of aspartate.

Authors:  S Usami; K K Osen; N Zhang; O P Ottersen
Journal:  Exp Brain Res       Date:  1992       Impact factor: 1.972

4.  Heat shock response in noise-induced hearing loss: effects of alanyl-glutamine dipeptide supplementation on heat shock proteins status.

Authors:  Marcos Soares; Analu B Dos Santos; Tainara M Weich; Gabriela Gomes Mânica; Paulo Ivo Homem de Bittencourt; Mirna Stela Ludwig; Thiago Gomes Heck
Journal:  Braz J Otorhinolaryngol       Date:  2019-06-08
  4 in total

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