Literature DB >> 6140950

Sulphate conjugation of beta 2-adrenoceptor stimulating drugs by platelet and placental phenol sulphotransferase.

R J Sodha, H Schneider.   

Abstract

A possible route of metabolism of beta-adrenoceptor stimulating drugs used in obstetrics consists of conjugation by the enzyme phenol sulphotransferase. The substrate specificities of the platelet and the placental enzymes towards these drugs were tested. The specific activities of the beta-adrenoceptor agonists were found to be relatively similar to those obtained with the catecholamine dopamine but their Km values were considerably higher.

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Year:  1984        PMID： 6140950      PMCID： PMC1463312          DOI： 10.1111/j.1365-2125.1984.tb05009.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  7 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  [Pharmacokinetic studies on 3H-hexoprenaline in the rat].

Authors:  B Kamper; S Leodolter; G Hellmann; G Hertting
Journal:  Arzneimittelforschung       Date:  1973-05

3.  The metabolism of terbutaline in vitro by rat and human liver O-methyltransferases and monoamine oxidases.

Authors:  K Persson; K Persson
Journal:  Xenobiotica       Date:  1972-07       Impact factor: 1.908

4.  Phenolsulphotransferase in human placenta.

Authors:  R J Sodha; V Glover; M Sandler
Journal:  Biochem Pharmacol       Date:  1983-05-15       Impact factor: 5.858

5.  Multiple forms of phenolsulphotransferase in human tissues: selective inhibition by dichloronitrophenol.

Authors:  G Rein; V Glover; M Sandler
Journal:  Biochem Pharmacol       Date:  1982-05-15       Impact factor: 5.858

6.  Sulphate conjugation of biologically active monoamines and their metabolites by human platelet phenolsulphotransferase.

Authors:  G Rein; V Glover; M Sandler
Journal:  Clin Chim Acta       Date:  1981-04-09       Impact factor: 3.786

7.  Human platelet phenolsulphotransferase: separate control of the two forms and activity range in depressive illness.

Authors:  S M Carter; V Glover; M Sandler; P K Gillman; P K Bridges
Journal:  Clin Chim Acta       Date:  1981-12-24       Impact factor: 3.786
  7 in total
  6 in total

1.  Stereoselective sulphate conjugation of racemic terbutaline by human liver cytosol.

Authors:  T Walle; U K Walle
Journal:  Br J Clin Pharmacol       Date:  1990-07       Impact factor: 4.335

2.  MRP isoforms and BCRP mediate sulfate conjugate efflux out of BeWo cells.

Authors:  Pallabi Mitra; Kenneth L Audus
Journal:  Int J Pharm       Date:  2009-09-25       Impact factor: 5.875

Review 3.  Drug transfer and metabolism by the human placenta.

Authors:  Michael R Syme; James W Paxton; Jeffrey A Keelan
Journal:  Clin Pharmacokinet       Date:  2004       Impact factor: 6.447

4.  Expression and functional activities of selected sulfotransferase isoforms in BeWo cells and primary cytotrophoblast cells.

Authors:  Pallabi Mitra; Kenneth L Audus
Journal:  Biochem Pharmacol       Date:  2009-07-30       Impact factor: 5.858

Review 5.  Models for placental transfer studies of drugs.

Authors:  P Bourget; C Roulot; H Fernandez
Journal:  Clin Pharmacokinet       Date:  1995-02       Impact factor: 6.447

Review 6.  Clinical pharmacokinetics of beta-agonists.

Authors:  D J Morgan
Journal:  Clin Pharmacokinet       Date:  1990-04       Impact factor: 6.447
  6 in total

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