Literature DB >> 6140424

Removal of neuroblastoma cells from bone marrow with monoclonal antibodies conjugated to magnetic microspheres.

J G Treleaven, F M Gibson, J Ugelstad, A Rembaum, T Philip, G D Caine, J T Kemshead.   

Abstract

Monoclonal antibodies bound to polystyrene microspheres containing magnetite have been used to remove tumour cells from bone marrow destined for autologous transplantation. The small magnetic beads can be targeted to the surface of tumour cells to render these magnetic. A flow system using permanent samarium cobalt magnets effects the rapid and efficient removal of "magnetic" tumour cells from bone marrow. The system is designed to be used with any type of tumour cell, so that by changing panels of monoclonal antibody it can be used for "cleaning" the bone marrow in many different malignancies.

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Year:  1984        PMID： 6140424     DOI： 10.1016/s0140-6736(84)90004-7

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  18 in total

1.  Differential interaction of magnetic nanoparticles with tumor cells and peripheral blood cells.

Authors:  J H Clement; M Schwalbe; N Buske; K Wagner; M Schnabelrauch; P Görnert; K O Kliche; K Pachmann; W Weitschies; K Höffken
Journal:  J Cancer Res Clin Oncol       Date:  2006-01-24       Impact factor: 4.553

2.  Phototoxic liposomes coupled to an antibody that alone cannot modulate its cell-surface antigen kill selected target cells.

Authors:  S Yemul; C Berger; M Katz; A Estabrook; R Edelson; H Bayley
Journal:  Cancer Immunol Immunother       Date:  1990       Impact factor: 6.968

3.  Multiplexed enrichment and detection of malarial biomarkers using a stimuli-responsive iron oxide and gold nanoparticle reagent system.

Authors:  Michael A Nash; John N Waitumbi; Allan S Hoffman; Paul Yager; Patrick S Stayton
Journal:  ACS Nano       Date:  2012-07-24       Impact factor: 15.881

Review 4.  Monoclonal antibodies in clinical medicine.

Authors:  H M Dick
Journal:  Br Med J (Clin Res Ed)       Date:  1985-09-21

5.  Selective killing of T lymphocytes by phototoxic liposomes.

Authors:  S Yemul; C Berger; A Estabrook; S Suarez; R Edelson; H Bayley
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205

Review 6.  Magnetic separation techniques: their application to medicine.

Authors:  J T Kemshead; J Ugelstad
Journal:  Mol Cell Biochem       Date:  1985-05       Impact factor: 3.396

Review 7.  Graft-versus-host disease: a review.

Authors:  A J Barrett
Journal:  J R Soc Med       Date:  1987-06       Impact factor: 5.344

8.  Monoclonal antibodies in diagnosis and treatment.

Authors:  G Morgan; R J Levinsky
Journal:  Arch Dis Child       Date:  1985-02       Impact factor: 3.791

9.  A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells.

Authors:  M F Clarke; I J Apel; M A Benedict; P G Eipers; V Sumantran; M González-García; M Doedens; N Fukunaga; B Davidson; J E Dick; A J Minn; L H Boise; C B Thompson; M Wicha; G Núñez
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-21       Impact factor: 11.205

10.  Induction of stable chimerism and elimination of graft-versus-host disease by depletion of T lymphocytes from bone marrow using immunomagnetic beads.

Authors:  A L Hoffman; L Makowka; D V Cramer; X Cai; B Banner; A Pascualone; S Hoffmann; T E Starzl
Journal:  Surgery       Date:  1989-08       Impact factor: 3.982
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