| Literature DB >> 6140342 |
Y F Lau, J C Huang, A M Dozy, Y W Kan.
Abstract
A recombinant DNA probe was used for antenatal sex determination. The probe was isolated from the 3.4 kilobase human repeat sequence derived from heterochromatin of the Y chromosome and had 1000 times more affinity for male DNA than for female DNA. A dot blot hybridisation method with 200 microliter of amniotic fluid yielded accurate results in 2 to 3 days. This test should facilitate antenatal diagnosis of sex-linked genetic disorders.Entities:
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Year: 1984 PMID： 6140342 DOI： 10.1016/s0140-6736(84)90182-x
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321