Literature DB >> 6140066

Penile erection: possible role for vasoactive intestinal polypeptide as a neurotransmitter.

B Ottesen, G Wagner, R Virag, J Fahrenkrug.   

Abstract

Concentrations of vasoactive intestinal polypeptide were measured in blood drawn from the cavernous spaces of corpus cavernosum of the human penis during tumescence and erection, and the effect of injecting the polypeptide into the cavernous spaces was studied. A significant release of the polypeptide was shown during tumescence and erection. Injection of exogenous vasoactive intestinal polypeptide induced erection. These findings support the concept of vasoactive intestinal polypeptide as a neurotransmitter in penile erection and suggest that it might have a clinical use in patients suffering from erectile dysfunction.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6140066      PMCID： PMC1444192          DOI： 10.1136/bmj.288.6410.9

Source DB:  PubMed          Journal:  Br Med J (Clin Res Ed)        ISSN： 0267-0623


  10 in total

1.  Comparative study of some isolated mammalian smooth muscle effectors of penile erection.

Authors:  E Klinge; N O Sjöstrand
Journal:  Acta Physiol Scand       Date:  1977-07

2.  Structure of the porcine vasoactive intestinal octacosapeptide. The amino-acid sequence. Use of kallikrein in its determination.

Authors:  V Mutt; S I Said
Journal:  Eur J Biochem       Date:  1974-03-01

3.  Principal mechanisms controlling penile retraction and protrusion in rabbits.

Authors:  N O Sjöstrand; E Klinge
Journal:  Acta Physiol Scand       Date:  1979-06

Review 4.  Vasoactive intestinal polypeptide: measurement, distribution and putative neurotransmitter function.

Authors:  J Fahrenkrug
Journal:  Digestion       Date:  1979       Impact factor: 3.216

5.  Radioimmunoassay of vasoactive intestinal polypeptide (VIP) in plasma.

Authors:  J Fahrenkrug; O V Schaffalitzky de Muckadell
Journal:  J Lab Clin Med       Date:  1977-06

6.  Vipergic nerves in the penis.

Authors:  J M Polak; J Gu; S Mina; S R Bloom
Journal:  Lancet       Date:  1981-08-01       Impact factor: 79.321

7.  Vasoactive intestinal polypeptide (VIP) as a putative neurotransmitter in penile erection.

Authors:  E A Willis; B Ottesen; G Wagner; F Sundler; J Fahrenkrug
Journal:  Life Sci       Date:  1983-07-25       Impact factor: 5.037

8.  Cavernosal alpha-blockade: a new technique for investigating and treating erectile impotence.

Authors:  G S Brindley
Journal:  Br J Psychiatry       Date:  1983-10       Impact factor: 9.319

Review 9.  Vasoactive intestinal polypeptide as a neurotransmitter in the female genital tract.

Authors:  B Ottesen
Journal:  Am J Obstet Gynecol       Date:  1983-09-15       Impact factor: 8.661

10.  Vasoactive intestinal polypeptide (VIP) as a possible neurotransmitter involved in penile erection.

Authors:  E Willis; B Ottesen; G Wagner; F Sundler; J Fahrenkrug
Journal:  Acta Physiol Scand       Date:  1981-12
  10 in total
  20 in total

Review 1.  Regulation of tone in penile cavernous smooth muscle. Established concepts and new findings.

Authors:  K E Andersson; F Holmquist
Journal:  World J Urol       Date:  1994       Impact factor: 4.226

2.  Aetiological factors and management of priapism in Bristol 1978-1983.

Authors:  A V Kaisary; P J Smith
Journal:  Ann R Coll Surg Engl       Date:  1986-09       Impact factor: 1.891

3.  Increased vaginal blood flow induced by implant electrical stimulation of sacral anterior roots in the conscious woman: a case study.

Authors:  R J Levin; R P Macdonagh
Journal:  Arch Sex Behav       Date:  1993-10

4.  Learning and sexual deficiencies in transgenic mice carrying a chimeric vasoactive intestinal peptide gene.

Authors:  I Gozes; J Glowa; D E Brenneman; S K McCune; E Lee; H Westphal
Journal:  J Mol Neurosci       Date:  1993       Impact factor: 3.444

5.  A fatty neuropeptide. Potential drug for noninvasive impotence treatment in a rat model.

Authors:  I Gozes; M Fridkin
Journal:  J Clin Invest       Date:  1992-09       Impact factor: 14.808

6.  Lack of circadian rhythm of plasma concentrations of vasoactive intestinal peptide in patients with orthotopic heart transplants.

Authors:  P Cugini; P Lucia; G Scibilia; L Di Palma; A R Cioli; A Cianetti; L Gasbarrone; R Canova; B Marino
Journal:  Br Heart J       Date:  1993-10

7.  Autonomic control of penile erection in the dog.

Authors:  C J Carati; K E Creed; E J Keogh
Journal:  J Physiol       Date:  1987-03       Impact factor: 5.182

8.  Role of the nitric oxide pathway and the endocannabinoid system in neurogenic relaxation of corpus cavernosum from biliary cirrhotic rats.

Authors:  M Ghasemi; H Sadeghipour; H Shafaroodi; B G Nezami; T Gholipour; A R Hajrasouliha; S Tavakoli; M Nobakht; K P Moore; A R Mani; A R Dehpour
Journal:  Br J Pharmacol       Date:  2007-05-08       Impact factor: 8.739

9.  Evidence against vasoactive intestinal polypeptide as the relaxant neurotransmitter in human cavernosal smooth muscle.

Authors:  R S Pickard; P H Powell; M A Zar
Journal:  Br J Pharmacol       Date:  1993-02       Impact factor: 8.739

10.  Effect of bromocriptine in patients with apomorphine-responsive erectile impotence: an open study.

Authors:  S Lal; M E Kiely; J X Thavundayil; J D Stewart; P Assalian; C F Ackman
Journal:  J Psychiatry Neurosci       Date:  1991-12       Impact factor: 6.186
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.