Literature DB >> 6140041

Effects of alpha-adrenoceptor antagonists on clonidine-induced inhibition of insulin secretion by isolated pancreatic islets.

J Langer, U Panten, S Zielmann.   

Abstract

The effects of clonidine, yohimbine, corynanthine and prazosin on glucose-induced insulin secretion by incubated or perifused mouse pancreatic islets were investigated. Clonidine (0.1 microM) inhibited glucose-induced insulin secretion alone and in the presence of yohimbine (0.1 microM), corynanthine (10 microM) or prazosin (1 microM). In higher concentrations, yohimbine (1-10 microM) antagonized the inhibitory effect of clonidine (0.1 microM) upon glucose-induced insulin secretion by incubated islets and by perifused islets. The results support the view that adrenergic inhibition of insulin secretion is mediated by alpha 2-adrenoceptors on pancreatic beta-cells.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6140041      PMCID： PMC2044869          DOI： 10.1111/j.1476-5381.1983.tb11014.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  30 in total

1.  Pre- and postsynaptic effects of yohimbine stereoisomers on noradrenergic transmission in the pulmonary artery of the rabbit.

Authors:  R Weitzell; T Tanaka; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-08       Impact factor: 3.000

2.  A versatile microperifusion system.

Authors:  U Panten; H Ishida; P Schauder; H Frerichs; A Hasselblatt
Journal:  Anal Biochem       Date:  1977-10       Impact factor: 3.365

3.  Insulin release by isolated pancreatic islets of the mouse incubated in vitro.

Authors:  E Coll-Garcia; J R Gill
Journal:  Diabetologia       Date:  1969-04       Impact factor: 10.122

4.  Effects of possible beta-cell membrane label, metahexamide-isothiocyanate, on insulin release.

Authors:  H G Joost
Journal:  Horm Metab Res       Date:  1979-02       Impact factor: 2.936

5.  Comparison of streptozotocin and alloxan-induced diabetes in the rat, including volumetric quantitation of the pancreatic islets.

Authors:  V Hoftiezer; A M Carpenter
Journal:  Diabetologia       Date:  1973-06       Impact factor: 10.122

6.  Studies of a simplified plasma insulin immunoassaay using cellulose powder.

Authors:  D S Zaharko; L V Beck
Journal:  Diabetes       Date:  1968-07       Impact factor: 9.461

7.  Recognition of insulin-releasing fuels by pancreatic B-cells: alpha-ketoisocaproic acid is an appropriate model compound to study the role of B-cell metabolism.

Authors:  U Panten; J Biermann; W Graen
Journal:  Mol Pharmacol       Date:  1981-07       Impact factor: 4.436

Review 8.  Alpha-adrenoceptor subclassification.

Authors:  K Starke
Journal:  Rev Physiol Biochem Pharmacol       Date:  1981       Impact factor: 5.545

9.  Insulin release. Demonstration of a priming effect of 3-isobutyl-1-methyl-xanthine (IBMX) on islets of Langerhans.

Authors:  D E Wiedenkeller; G W Sharp
Journal:  Diabetes       Date:  1981-09       Impact factor: 9.461

10.  Mode of action of clonidine upon islet function: dissociated effects upon the time course and magnitude of insulin release.

Authors:  V Leclercq-Meyer; A Herchuelz; I Valverde; E Couturier; J Marchand; W J Malaisse
Journal:  Diabetes       Date:  1980-03       Impact factor: 9.461
View more
  15 in total

Review 1.  Biological significance of agmatine, an endogenous ligand at imidazoline binding sites.

Authors:  W Raasch; U Schäfer; J Chun; P Dominiak
Journal:  Br J Pharmacol       Date:  2001-07       Impact factor: 8.739

2.  A preliminary, clinical pharmacological assessment of L-659,066, a novel alpha 2-adrenoceptor antagonist.

Authors:  R F Schafers; H L Elliott; C A Howie; J L Reid
Journal:  Br J Clin Pharmacol       Date:  1992-12       Impact factor: 4.335

3.  Effects of Bordetella pertussis toxin on catecholamine inhibition of insulin release from intact and electrically permeabilized rat islets.

Authors:  S J Persaud; P M Jones; S L Howell
Journal:  Biochem J       Date:  1989-03-15       Impact factor: 3.857

4.  Dual action of clonidine on insulin release: suppression, but stimulation when alpha 2-adrenoceptors are blocked.

Authors:  A Schulz; A Hasselblatt
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-12       Impact factor: 3.000

5.  Proceedings of the British Pharmacological Society. 6th-8th January, 1988. Abstracts.

Authors: 
Journal:  Br J Pharmacol       Date:  1988-03       Impact factor: 8.739

6.  Effects of isoprenaline and glucagon on insulin secretion from pancreatic islets.

Authors:  S Zielmann; G Schütte; S Lenzen; U Panten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-05       Impact factor: 3.000

7.  An insulin-releasing property of imidazoline derivatives is not limited to compounds that block alpha-adrenoceptors.

Authors:  A Schulz; A Hasselblatt
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-09       Impact factor: 3.000

8.  Phentolamine, a deceptive tool to investigate sympathetic nervous control of insulin release.

Authors:  A Schulz; A Hasselblatt
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-06       Impact factor: 3.000

9.  Evidence that the novel imidazoline compound FT005 is an alpha(2)-adrenoceptor agonist.

Authors:  Scott Slough; Gerald Guillaumet; Peter V Taberner
Journal:  Br J Pharmacol       Date:  2002-08       Impact factor: 8.739

10.  Stimulation of insulin secretion by imidazoline compounds is not due to interaction with non-adrenoceptor idazoxan binding sites.

Authors:  C A Brown; A C Loweth; S A Smith; N G Morgan
Journal:  Br J Pharmacol       Date:  1993-02       Impact factor: 8.739
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.