Literature DB >> 6139136

Effects of apamin on alpha-adrenoceptor-mediated changes in plasma potassium in guinea-pigs.

R A Coats.   

Abstract

An intravenous K+-sensitive electrode has been used to monitor plasma [K+] changes induced by adrenaline (1.4-6.8 micrograms kg-1) and amidephrine (14-340 micrograms kg-1) in anaesthetized guinea-pigs. A biphasic response consisting of an initial increase in [K+] followed, within 1 min, by a fall below baseline was observed with both agonists. Apamin (0.4-40 micrograms kg-1) reduced the hyperkalaemic phase of the response to amidephrine in a dose-related, non-competitive manner. The response to adrenaline was also reduced but to a lesser extent. Apamin caused little or no reduction of the hypokalaemic phase of the response to either agonist.

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Year:  1983        PMID： 6139136      PMCID： PMC2044995          DOI： 10.1111/j.1476-5381.1983.tb10731.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  29 in total

1.  MECHANISM OF THE POTASSIUM MOBILIZING ACTION OF EPINEPHRINE AND GLUCAGON.

Authors:  S ELLIS; S B BECKETT
Journal:  J Pharmacol Exp Ther       Date:  1963-12       Impact factor: 4.030

2.  Observations on epinephrine and glucagon-induced glycogenolysis and potassium loss in the isolated perfused frog liver.

Authors:  A B CRAIG
Journal:  Am J Physiol       Date:  1958-05

3.  The effect of sympathomimetic amines on arterial plasma potassium and cardiac rhythm in anesthetized dogs.

Authors:  G S O'BRIEN; Q R MURPHY; W J MEEK
Journal:  J Pharmacol Exp Ther       Date:  1953-12       Impact factor: 4.030

4.  Apamin blocks certain neurotransmitter-induced increases in potassium permeability.

Authors:  B E Banks; C Brown; G M Burgess; G Burnstock; M Claret; T M Cocks; D H Jenkinson
Journal:  Nature       Date:  1979-11-22       Impact factor: 49.962

5.  Isoproterenol-induced hypokalemia: role of the liver.

Authors:  J R Jauchem; R L Vick
Journal:  Proc Soc Exp Biol Med       Date:  1979-10

6.  Kalemotropic effect of epinephrine: analysis with adrenergic agonists and antagonists.

Authors:  E P Todd; R L Vick
Journal:  Am J Physiol       Date:  1971-06

7.  Effects of isomers of the alpha-agonist amidephrine on arterial and tracheal muscle in vitro.

Authors:  A B Buchthal; D H Jenkinson
Journal:  Eur J Pharmacol       Date:  1970-05       Impact factor: 4.432

8.  Relationship of hyperkalemic response to hepatic phosphorylase activation induced by adrenaline.

Authors:  A Tsujimoto; S Tanino; K Kaniike; K Seto; Y Kurogochi
Journal:  Jpn J Pharmacol       Date:  1965-12

9.  Effects of sympathomimetic amines on 45Ca efflux from liver slices.

Authors:  D G Haylett
Journal:  Br J Pharmacol       Date:  1976-05       Impact factor: 8.739

10.  Effects of noradrenaline on potassium reflux, membrane potential and electrolyte levels in tissue slices prepared from guinea-pig liver.

Authors:  D G Haylett; D H Jenkinson
Journal:  J Physiol       Date:  1972-09       Impact factor: 5.182
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  3 in total

1.  Cardiovascular effects of apamin and BRL 34915 in rats and rabbits.

Authors:  N S Cook; R P Hof
Journal:  Br J Pharmacol       Date:  1988-01       Impact factor: 8.739

2.  The effect of noradrenaline on the ion permeability of isolated mammalian hepatocytes, studied by intracellular recording.

Authors:  A C Field; D H Jenkinson
Journal:  J Physiol       Date:  1987-11       Impact factor: 5.182

3.  The effects of adrenoceptor agonists and antagonists on plasma potassium concentration in anaesthetized guinea-pigs, rabbits and rats.

Authors:  R A Coats
Journal:  Br J Pharmacol       Date:  1985-12       Impact factor: 8.739
  3 in total

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