Antihypertensives and their impact on renal function.

Antihypertensive agents possess many properties that could cause alterations in renal function. These are: alterations in systemic hemodynamics, changes in the renin-angiotensin aldosterone system, direct intrarenal effects, and alterations in salt and water metabolism. This article reviews the antihypertensive agents in general usage and major points are made concerning potential deleterious effects of methyldopa and nonselective beta-adrenergic blocking drugs on renal function. In particular, recent data are shown concerning the effects of labetalol on renal function indicating the absence of decrements in glomerular filtration rate and renal plasma flow in patients with normal renal function and in patients with mild to moderate renal insufficiency. A possible decrease in these parameters in patients with severe renal insufficiency is presented and discussed.