| Literature DB >> 6138501 |
M C Pike, B E Henderson, M D Krailo, A Duke, S Roy.
Abstract
A case-control study of 314 breast cancer patients aged less than 37 at diagnosis and 314 individually matched controls was done to assess the influence of oral-contraceptive (OC) use on the risk of the disease. Long-term use before age 25 of combination-type OCs with a "high" content of the progestogen component was associated with increased risk of breast cancer: the relative risk was approximately 4 after 5 years of such use, and 9 cases and no controls had used such combination-type OCs for more than 6 years before age 25. Use of combination-type OCs with a "low" progestogen component appears to increase breast-cancer risk little or not at all.Entities:
Keywords: Age Factors; Biology; Birth Order; Breast Cancer; Cancer; Contraception; Contraceptive Agents; Contraceptive Agents, Female; Contraceptive Methods--side effects; Control Groups; Demographic Factors; Diseases; Endocrine System; Estrogens; Family And Household; Family Characteristics; Family Planning; Family Relationships; Fertility; Fertility Measurements; First Birth; High Risk Women; Hormones; Menarche; Menopause; Neoplasms; Oral Contraceptives, Combined; Oral Contraceptives--side effects; Physiology; Population; Population Characteristics; Population Dynamics; Pregnancy History; Progestational Hormones; Progesterone; Reproduction; Reproductive Control Agents; Research Methodology; Time Factors
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Year: 1983 PMID： 6138501 DOI： 10.1016/s0140-6736(83)90450-6
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321