Literature DB >> 6138122

Enhancement of desynchronized sleep signs after pontine microinjection of the muscarinic agonist bethanechol.

J A Hobson, M Goldberg, E Vivaldi, D Riew.   

Abstract

The question of which brainstem neuronal receptors can mediate cholinergic REM sleep induction was investigated by injecting the pure muscarinic agonist bethanechol via glass micropipettes in the pontine tegmentum of cats. The REM sleep enhancement was observed to be equally potent, equally dose-dependent and its appearance equally site-dependent as that previously observed with carbachol, a mixed muscarinic/nicotinic agonist. The results suggest that the pharmacological activation of muscarinic receptors in pontine neurons is sufficient to trigger REM sleep.

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Year:  1983        PMID： 6138122     DOI： 10.1016/0006-8993(83)90424-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  13 in total

Review 1.  Neurobiological mechanisms for the regulation of mammalian sleep-wake behavior: reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence.

Authors:  Subimal Datta; Robert Ross Maclean
Journal:  Neurosci Biobehav Rev       Date:  2007-03-12       Impact factor: 8.989

2.  Modulation of desynchronized sleep through microinjection of beta-adrenergic agonists and antagonists in the dorsal pontine tegmentum of the cat.

Authors:  G Tononi; M Pompeiano; O Pompeiano
Journal:  Pflugers Arch       Date:  1989-11       Impact factor: 3.657

3.  Release of acetylcholine and GABA, and activity of their synthesizing enzymes in the rat pontine reticular formation.

Authors:  I Camacho-Arroyo; R Alvarado; R Tapia
Journal:  Neurochem Res       Date:  1991-08       Impact factor: 3.996

Review 4.  The organization and regulation of sleep. A review of the experimental evidence and a novel integrated model of the organizing and regulating apparatus.

Authors:  W P Koella
Journal:  Experientia       Date:  1984-04-15

5.  Role of central alpha-1 adrenoceptors in canine narcolepsy.

Authors:  E Mignot; C Guilleminault; S Bowersox; A Rappaport; W C Dement
Journal:  J Clin Invest       Date:  1988-09       Impact factor: 14.808

6.  Prostaglandin E2 and its methyl ester reduce cataplexy in canine narcolepsy.

Authors:  S Nishino; E Mignot; B Fruhstorfer; W C Dement; O Hayaishi
Journal:  Proc Natl Acad Sci U S A       Date:  1989-04       Impact factor: 11.205

7.  Discharge properties of medullary reticulospinal neurons during postural changes induced by intrapontine injections of carbachol, atropine and serotonin, and their functional linkages to hindlimb motoneurons in cats.

Authors:  K Takakusaki; N Shimoda; K Matsuyama; S Mori
Journal:  Exp Brain Res       Date:  1994       Impact factor: 1.972

8.  Synaptic mechanisms acting on lumbar motoneurons during postural augmentation induced by serotonin injection into the rostral pontine reticular formation in decerebrate cats.

Authors:  K Takakusaki; J Kohyama; K Matsuyama; S Mori
Journal:  Exp Brain Res       Date:  1993       Impact factor: 1.972

9.  Neuropharmacological characterization of basal forebrain cholinergic stimulated cataplexy in narcoleptic canines.

Authors:  M S Reid; S Nishino; M Tafti; J M Siegel; W C Dement; E Mignot
Journal:  Exp Neurol       Date:  1998-05       Impact factor: 5.330

10.  Neuromodulation of Astrocytic K+ Clearance.

Authors:  Alba Bellot-Saez; Rebecca Stevenson; Orsolya Kékesi; Evgeniia Samokhina; Yuval Ben-Abu; John W Morley; Yossi Buskila
Journal:  Int J Mol Sci       Date:  2021-03-03       Impact factor: 5.923
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