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Literature DB >> 6138062

Chemical structure and properties of midazolam compared with other benzodiazepines.

Abstract

A short review is given of the basic chemical development in the field of 'classical' and 'annelated' benzodiazepines, distinguishing between pro-drugs and directly acting compounds. Some properties of midazolam that are of special interest for its practical use are discussed, such as: the basicity of its imidazole ring nitrogen, which allows water-soluble salts and well-tolerated aqueous injectable solutions to be prepared; its stability to hydrolytic degradation; its rapid metabolic inactivation, which is mainly determined by the methyl group on the imidazole ring, and which is much faster than that of classical benzodiazepines.

Entities: Chemical

Mesh：

Substances：

Year: 1983 PMID： 6138062 PMCID： PMC1428108 DOI： 10.1111/j.1365-2125.1983.tb02266.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

14 in total

1. Clinical, electroencephalographic, and pharmacokinetic studies of a water-soluble benzodiazepine, midazolam maleate.

Authors: C R Brown; F H Sarnquist; C A Canup; T A Pedley
Journal: Anesthesiology Date: 1979-05 Impact factor: 7.892

2. The benzodiazepine story.

Authors: L H Sternbach
Journal: J Med Chem Date: 1979-01 Impact factor: 7.446

Review 3. The benzodiazepine story.

Authors: L H Sternbach
Journal: Prog Drug Res Date: 1978

4. Determination of water soluble imidazo-1,4-benzodiazepines in blood by electron- capture gas--liquid chromatography and in urine by differential pulse polaragraphy.

Authors: C V Puglisi; J C Meyer; L D'Arconte; A Brooks; J A de Silva
Journal: J Chromatogr Date: 1978-01-01

5. Anxiolytic sedatives. 1. Synthesis and pharmacology of benzo[6,7]-1,4-diazepino[5,4-b]oxazole derivatives and analogs.

Authors: T Miyadera; A Terada; M Fukunaga; Y Kawano; T Kamioka; C Tamura; H Takagi; R Tachikawa
Journal: J Med Chem Date: 1971-06 Impact factor: 7.446

Chemical structure and properties of midazolam compared with other benzodiazepines.

1. Clinical, electroencephalographic, and pharmacokinetic studies of a water-soluble benzodiazepine, midazolam maleate.

2. The benzodiazepine story.

Review 3. The benzodiazepine story.

4. Determination of water soluble imidazo-1,4-benzodiazepines in blood by electron- capture gas--liquid chromatography and in urine by differential pulse polaragraphy.

5. Anxiolytic sedatives. 1. Synthesis and pharmacology of benzo[6,7]-1,4-diazepino[5,4-b]oxazole derivatives and analogs.

6. Studies on the metabolism of oxazolam. II. Isolation and identification of the metabolites of oxazolam in rats.

7. Pharmacokinetics and bioavailability of midazolam in man.

8. The pharmacokinetics of midazolam in man.

9. Excretion and metabolism of 14C-midazolam in humans following oral dosing.

10. Triazolam disposition.

Review 1. Adult sedation: oral, rectal, IM, IV.

Review 2. Pharmacology of drugs frequently used in ICUs: midazolam and flumazenil.

3. [Analytic data of the new benzodiazepine derivative midazolam (Dormicum) and its metabolites].

Review 4. Anaesthetic premedication: aims, assessment and methods.

Review 5. Amide Bond Bioisosteres: Strategies, Synthesis, and Successes.

Review 6. Midazolam: a new drug for intravenous sedation.

Review 7. Midazolam: review of a versatile agent for use in dentistry.

8. The pharmacokinetics of midazolam in paediatric patients.

Review 9. New intravenous anaesthetics and neuromuscular blocking drugs. A review of their properties and clinical use.

10. Effects of oral and intravenous midazolam, triazolam and flunitrazepam on the sleep-wakefulness cycle of rabbits.