Literature DB >> 6137826

Serotonin receptors induced by exogenous messenger RNA in Xenopus oocytes.

C B Gundersen, R Miledi, I Parker.   

Abstract

When poly(A)+-mRNA, extracted from rat brain, was injected into Xenopus laevis oocytes, it induced the appearance of serotonin receptors in the oocyte membrane. Application of serotonin to injected oocytes elicited, after a long delay, oscillations in membrane current. The equilibrium potential of this current corresponded with the chloride equilibrium potential. It appears that rat brain mRNA encodes the translation of serotonin receptors into the oocyte membrane. The combination of serotonin with these receptors leads to the opening of membrane channels.

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Year:  1983        PMID： 6137826     DOI： 10.1098/rspb.1983.0062

Source DB:  PubMed          Journal:  Proc R Soc Lond B Biol Sci        ISSN： 0950-1193


  31 in total

1.  Effects of defolliculation on membrane current responses of Xenopus oocytes.

Authors:  R Miledi; R M Woodward
Journal:  J Physiol       Date:  1989-09       Impact factor: 5.182

Review 2.  Use of Xenopus oocytes for the functional expression of plasma membrane proteins.

Authors:  E Sigel
Journal:  J Membr Biol       Date:  1990-09       Impact factor: 1.843

3.  Receptors of the serotonin 1C subtype expressed from cloned DNA mediate the closing of K+ membrane channels encoded by brain mRNA.

Authors:  M M Panicker; I Parker; R Miledi
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

4.  Coupling of inositol phospholipid hydrolysis to peptide hormone receptors expressed from adrenal and pituitary mRNA in Xenopus laevis oocytes.

Authors:  R P McIntosh; K J Catt
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

5.  Oscillatory chloride current evoked by temperature jumps during muscarinic and serotonergic activation in Xenopus oocyte.

Authors:  R Miledi; I Parker; K Sumikawa
Journal:  J Physiol       Date:  1987-02       Impact factor: 5.182

6.  Expressional potency of mRNAs encoding receptors and voltage-activated channels in the postmortem rat brain.

Authors:  D S Ragsdale; R Miledi
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-01       Impact factor: 11.205

7.  Inhibition by Ca2+ of inositol trisphosphate-mediated Ca2+ liberation: a possible mechanism for oscillatory release of Ca2+.

Authors:  I Parker; I Ivorra
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

8.  Enhancement by 5-hydroxytryptamine and analogues of desensitization of neuronal and muscle nicotinic receptors expressed in Xenopus oocytes.

Authors:  K M Cross; R C Foreman; J E Chad
Journal:  Br J Pharmacol       Date:  1995-04       Impact factor: 8.739

Review 9.  High throughput electrophysiology with Xenopus oocytes.

Authors:  Roger L Papke; Cathy Smith-Maxwell
Journal:  Comb Chem High Throughput Screen       Date:  2009-01       Impact factor: 1.339

10.  Actions of dopamine and dopaminergic drugs on cloned serotonin receptors expressed in Xenopus oocytes.

Authors:  R M Woodward; M M Panicker; R Miledi
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-15       Impact factor: 11.205
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